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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Interferon and p 53 Tumor Suppressor Marker in Hepatocellular Carcinoma

Author: HEND OKASHA
Abstract: Interferons are a group of cytokines secreted by many cell types of the immune system. They are classified into three classes according to gene chromosomal location and type of binding receptors. Interferons may be bear a resemblance to general mode of action as antiviral, antiproliferative and immunomodulatory properties. For years till now each type of interferon is used as therapeutic drug in treatment of various diseases. This review emphasis on the relation between apoptotic marker p53 in hepatocellular carcinoma and interferons. The primary cancer of the liver cells is hepatocellular carcinoma. Classical apoptotic properties of certain forms of tumor cells are apparent when they were subjected to DNA fragmentation and cell shrinking, chromatin condensation, etc. These symptoms lead to apoptotic markers being expressed or suppressed of tumor markers as an indicator to IFN induced apoptosis. The main question is that: Have any type of interferons could be potent inducer of p53 expression? Which will be presented.
Keyword: Interferon alpha, Interferon beta, Interferon gamma, Interferon lambda, p53, Hepatocellular carcinoma
DOI: https://doi.org/10.31838/ijpr/2020.12.02.0008
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