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Evaluation of Antiulcer Activity of Extract of Calycophyllum Spruceanum (Benth) Bark
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| Author:
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VENKATAIAH GUDISE, DR. I VEENA RANI, P. LAXMI SUMA, R. SHREYA GUPTA, R. BHAVYA SRI
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| Abstract:
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Objective The objective of the study was to evaluate the antiulcer activity of ethanolic extract of Calycophyllum spruceanum bark.
Methodology The ethanol-HCL and pylorus ligation induced models was selected using swiss albino mice and the animals were fasted overnight and then grouped as negative control (0.9% normal saline), standard (omeprazole 30mg/kg), test 1 (CSBE 100mg/kg) and test 2 (CSBE 200mg/kg). The ulcer score, ulcer index and percent ulcer inhibition were determined in ethanol/HCL model. The volume of gastric secretion, pH, total acidity, ulcer index and percent of ulcer inhibition was determined in pylorus ligation model. The ulcerogenic abrasions in the mucosal membrane were observed under a microscope (10X) and scored manually.
Results The preliminary phytochemical screening indicated the presence of sterols, alkaloids, glycosides, flavonoids, saponins and coumarins. The bark extract was tolerable at dose of 2000mg/kg. The selected doses of the extracts of 100, 200mg/kg was shown the significant and dose dependent antiulcer activity in ethanol/HCL and pylorus-ligation models as 11.08 %, 32.59% and 28.29%, 37.03% respectively. The dose of 200mg/kg of CSBE was shown the superlative activity ((#p?0.001)) in both models.
Conclusion: It was concluded that, the ethanolic extract of Calycophyllum spruceanum bark has a significant antiulcer activity. This activity might be due to presence of supportive phytochemical like flavonoids, alkaloids, steroids. and glycosides. Hence, further evaluation is needed to isolate and identify the specific constituents responsible for the activity.
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| Keyword:
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Calycophyllum spuceanum; Ethanol-HCL; Pylorus-ligation; Antiulcer activity.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.01.070
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| Download:
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