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Correlation of Calprotectin with Galectin 33, Adropin and CTLA-4 in Iraqi Rheumatoid Arthritis Patients
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| Author:
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SHAKIR T.
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| Abstract:
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Background
Rheumatoid arthritis (RA) is a common autoimmune infection described by enduring inflammation and intersections destruction
Aim of the work
The current research was planned to measure the serum level of calprotectin (Calpro) in cases with RA & its correlation with the galectin-3 (GAL3), adropin (AD) and cytotoxic T lymphocyte as-sociated antigen-4 (CTLA-4).
Methods
The study concerned on 44 Iraqi patients of RA in compared with 40 healthy control (HC) matched for sex, age and ethnic background, erythrocyte sedimentation rate (ESR) was measured, while serum Calpro, GAL3, AD and CTLA-4 levels were estimated by means of sandwich ELISA test using commercially available kits.
Results
Serum Calpro, GAL3, CTLA4, was importantly greater (P<0.001) while vitamin D (VD) and AD was significantly lower (P<0.001) in RA patients when compared to control.
There was a significant positive association among Calpro and both of (GAL3 and CTLA4). A important negative relationship among Calpro and AD were observed
Conclusion
The present results explained that serum Calpro is a measurable, useful specific indicator of infection commotion and joint impairment in RA patients.
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| Keyword:
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Calprotectin, Galectin-3, Adropin, Rheumatoid Arthritis
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.01.052
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| Download:
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Request For Article
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