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Determination of Chlorpromazine Hydrochloride in its Pure and Dosage Forms by Diazotization Reaction and Coupling with Diazotized Sulfanilic Acid
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| Author:
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SAHAR FADHEL, ABBAS SHEBEEB AL-KADUMI, WADHAH HILAL ABDULLAH
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| Abstract:
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A simple and sensitive spectrophotometric method for determination trace amount of Chlorpromazine Hydrochloride (CLPZ) in tablet pharmaceutical preparations were described. The method was based on the coupling reaction of drug with (0.3 mole.L-1) diazonium salt (prepared from reaction of sulphanilic acid with (12.07 mole.L-1) hydrochloric acid and sodium nitrite at (0-5) ºC in basic medium of sodium hydroxide (0.5 mole.L-1) to produce pink color azo dye compound can be absorbed at 526nm, the optimum reaction conditions and other analytical parameters were evaluated. The high accurate and precise results obtained with RSD%, Recovery%, Ere% and D.L were 0.9333, 101.045, 1.0457, and 0.1114 µg.ml-1 respectively, the linearity of rang 2.0-100.0 µg.mL-1. The proposed method was successfully applied to the determination of CLPZ in pharmaceutical formulations without any effect of interference of chemical materials in pharmaceuticals.
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| Keyword:
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Chlorpromazine Hydrochloride, spectrophotometry, sulphanilic acid, azo dye.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.01.044
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| Download:
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