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Analyzing the Age Diversity of Patients with Colorectal Cancer
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| Author:
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O.N. ILINSKAYA, M.A. KHARITONOVA, A.N. DOYNIKOVA, B.I. GATAULLIN, P.V. ZELENIKHIN
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| Abstract:
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Of the goal of this investigation is to assess the number of primary diseases with colorectal cancer (CRC).
Based on this study the number has increased in recent 50 years in Russia. Analysis of patients with diagnosed
rectal cancer in the RT revealed that the overall incidence of KRAS mutations was 33%, 68% of cases with
mutations in the 12th codon, 33% of the detected mutant KRASs are homoduplexes. Patients older than 60
years carry the mutant KRAS, which nullifies the effectiveness of Epidermal Growth Factor receptor (EFGR)
inhibitors, in only 10% of cases. In the group of patients younger than 50 years, KRAS mutations were found in
58.3% of cases. The microbial profile of the biopsy specimens revealed a tendency for phylum Bacteroides and
Enterobacteriaceae to predominate on intact epithelium and replace them with tumor genera Faecalibacterium,
Streptococcus and Fusobacterium on tumor. The taxonomic structure of bacterial communities of biopsy
specimens is diverse; in tumor tissue, diversity can both decrease and increase. The representation of the
Prevotella genus in the epithelium with the mutant KRAS gene was increased in 50% of cases. Expanding the
spectrum of molecular targets in the epithelium and intestinal microbiome should ensure the effectiveness of
personified antitumor therapy.
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| Keyword:
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colorectal cancer, KRAS, microbiome, high-resolution melting method, metagenomic sequencing
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.01.149
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| Download:
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