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Spectrophotometric Determination of Olanzapine by Charge-Transfer Complex Formation in its Pure Form and Pharmaceutical Formulations
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| Author:
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HAMSA YASEEN, RUAA M. MAHMOOD, ROKAYIA S. SADEQ
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| Abstract:
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This study involved rapid, delicate and simple spectrophotometric procedure to determine the drug Olanzapine
(Ola.) in its pure form and pharmacological formulations. This reaction was built on Charge-Transfer complex
reaction between the basic nitrogen (The more basic secondary amine) of the drug as n-donor with ?-acceptor of
the -tetrachloro-1,4-benzoquinone- (Chloranil) (Chl.). The bluish-green colored formed was quantitatively
measured at 604 nm. The colored complex obeyed Beer’s law in the concentration range of (1-35) µg.ml
. The molar
absorptivity value obtained from Beer’s data was found to be 18215 L.mol
-1
, Sandell’s sensitivity value was calculated
to be 0.0172 µg.cm
-1
-1
.cm
-2
, while LOD and LOQ were found to be 0.0736 and 0.2229 µg.ml
-1
, respectively. The
stoichiometry of the complex established between the drug and (Chl.) was 1:1 as estimated by Job’s method of
continuous variation and mole ratio method. The association constant (KCT) of the Charge-Transfer complex
formative was evaluated using Benesi–Hildebrand equation and was found to be 400 L.mol
. The method was
successfully applied for the analysis of pharmaceutical formulations.
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| Keyword:
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Spectrophotometric Quantitative, Charge-Transfer Complex, tetrachloro-1,4-benzoquinone & Olanzapine.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.01.139
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| Download:
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