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Synthesis and biological evaluation of Schiff bases and pyrazole derivatives derive from chalcones, (2E)1-(4-aminophenyl)-3-(2-furyl)prop-2-en-1-one
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| Author:
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ALI HASSAN, HAMID H. MOHAMMED
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| Abstract:
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This work describes the synthesis of Schiff bases (2-8), pyrazoles and (9-18) derivatives from chalcones (1),
(2E)-1-(4-aminophenyl)-3-(2-furyl)prop-2-en-1-one, and some biological studies of these compounds against
(gram +ve) bacteria (Staphylococcus aureus and Staphylococcus epidermidis), and (gram –ve) bacteria (Escherichia
coli and Klebsiellapneumniae); and antifungal actioncontra (Candida albicans) .Series of biologically active
substituted Schiff bases(2-8) were synthesized from chalcone (1) and different substituted aldehyde compounds
in the presence of piperidine as catalysis and ethanol as a solvent.Some of Schiff bases compounds on reaction
with phenylhydrazine or hydrazinehydrate in ethanol as a solvent give pyrazole derivative (9-18). The
homogeneity of all the newly synthesized compounds has been checked by TLC. The chemical structures of
the newly synthesized compounds were confirmed by FTIR,
HNMR spectroscopic analysis, and the data are in
accord with the assigned structure.
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| Keyword:
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chalcone, Chiff bases, pyrazole, biological evaluation
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.01.138
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| Download:
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Request For Article
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