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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Effects of topical Phenytoin,Chitosan, Dextrin, and Chitosan-Dextrin Combinations in Experimentallyinduced Thermal Injury in Rabbits

Author: HMED ABD, ABDULKAREEM H. ABD, MUHAMMED A. H. ALDABAGH
Abstract: Phenytoin has been known to promote wound healing like burns injury because it owing to its proliferative as well as anti-inflammatory effects. the aim of this study to evaluate the effects of topical chitosan 2% cream (Ch ), alone and in combination with Phenytoin (Phenytoin 1%+Chitosan 1%)cream combination (PhCh )on experimentally- induced thermal injury in albino rabbits. Seventy two of albino male rabbits, weighing 1250-1750 g were divided into six groups, each of them 12 animals: AH group: apparently healthy rabbits, BWT group: treated with base Aqua Rosa cream, PhCh group: treated with phenytoin 1% ,chitosan 1% and dextrin prepared cream, Ch group: treated with chitosan 2%- dextrin,SSD group: treated with silver sulfadiazine cream (control ); all animals (except AH group ) were induced burn and treated topically on burned area twice daily for 28days. Tissue levels of vascular endothelial cell growth factor (VEGF ),transforming growth factor beta (TGF-ß ), and skin histopathological examination were measured on days 7, 14, 21, and 28 of burn injury experiment. Histopathologic evaluations at the day 7 showed that neovascularization, granulation tissue and collagen scores were greater in the PhCh group than the Ch, SSD and BWT groups. On day 21, re-epithelialization scores were showed higher and maximum level in the PhCh group than the Ch, SSD , and BWT groups. Inflammatory cells scores in BWT,SSD, and Ch groups showed higher than PhCh group . PhCh, Ch, and SSD groups have a significant increases in VEGF levels in compared with AH and BWT groups.Ch and SSD groups showed distinctive elevation in TGF-ß level while PhCh group still within normal level during sampling itervals.
Keyword: Phenytoin,vascular endothelial cell growth factor
DOI: https://doi.org/10.31838/ijpr/2020.12.01.061
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0.12
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