IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
Article In Press
Prevalence and Risk Factors of Occupation Induced Asthma among Traffic Police in Bangalore City
o Estimate the Prevalence of Depression, Anxiety, and Stress among Adolescents in Kancheepuram District, Tamil Nadu
A Study on Risk Factors of Anaemia among Pregnant Women
n Approach of Nutritional Deficiency Disorder among Pregnant Women
The Determinants of Self Care Practices By Using DSME to Facilitate the Patients In Kanchipuram District
An evaluation of Epidemiological Factors Relating to Overweight, Obesity in Urban Chennai
A study on the Pattern of Body Image Perception among Adolescents in Urban Chennai
mpact of an External and Internal factors of overweight and obesity in urban
A study on Anti-Rabies Vaccine among Dog Bite Victims in chennai region
Hospital Based Cross Sectional Study: Distribution of Compliance for completion of ARV 4 dose among study participants
12345678910...
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Effects of topical Phenytoin,Chitosan, Dextrin, and Chitosan-Dextrin Combinations in Experimentallyinduced Thermal Injury in Rabbits

Author: HMED ABD, ABDULKAREEM H. ABD, MUHAMMED A. H. ALDABAGH
Abstract: Phenytoin has been known to promote wound healing like burns injury because it owing to its proliferative as well as anti-inflammatory effects. the aim of this study to evaluate the effects of topical chitosan 2% cream (Ch ), alone and in combination with Phenytoin (Phenytoin 1%+Chitosan 1%)cream combination (PhCh )on experimentally- induced thermal injury in albino rabbits. Seventy two of albino male rabbits, weighing 1250-1750 g were divided into six groups, each of them 12 animals: AH group: apparently healthy rabbits, BWT group: treated with base Aqua Rosa cream, PhCh group: treated with phenytoin 1% ,chitosan 1% and dextrin prepared cream, Ch group: treated with chitosan 2%- dextrin,SSD group: treated with silver sulfadiazine cream (control ); all animals (except AH group ) were induced burn and treated topically on burned area twice daily for 28days. Tissue levels of vascular endothelial cell growth factor (VEGF ),transforming growth factor beta (TGF-ß ), and skin histopathological examination were measured on days 7, 14, 21, and 28 of burn injury experiment. Histopathologic evaluations at the day 7 showed that neovascularization, granulation tissue and collagen scores were greater in the PhCh group than the Ch, SSD and BWT groups. On day 21, re-epithelialization scores were showed higher and maximum level in the PhCh group than the Ch, SSD , and BWT groups. Inflammatory cells scores in BWT,SSD, and Ch groups showed higher than PhCh group . PhCh, Ch, and SSD groups have a significant increases in VEGF levels in compared with AH and BWT groups.Ch and SSD groups showed distinctive elevation in TGF-ß level while PhCh group still within normal level during sampling itervals.
Keyword: Phenytoin,vascular endothelial cell growth factor
DOI: https://doi.org/10.31838/ijpr/2020.12.01.061
Download: Request For Article
 












ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events
0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free
0.07
2017CiteScore
 
11th percentile
Powered by  Scopus