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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Antiinflammation Effect of Tabat Barito (Ficus deltoidea) Leaf Extract on Small Intestine of Mice Induced by Dextran Sodium Sulfate

Author: KUSMARDI KUSMARDI, RIZKY DINI FITRIYASA
Abstract: Purpose: To prove that tabat barito leaf extract has an anti-inflammatory effect on the small intestine of mice induced by dextran sodium sulfate (DSS). Methodology : This study used an experimental research method with DSS to induce colitis in mice. Mice were then given tabat barito leaf extract with a concentration of 25% w / v and 50% w / v to compare with mice given aspirin. Histopathological features of the small intestine mucosa are observed (hematoxylin-eosin staining) to determine intestinal inflammatory variables including infiltration of inflammatory cells, angiogenesis, and loss of goblet cells. Histopathological features were observed in 5 visual fields for each preparation. Results: Statistical tests revealed that there was no significant effect of tabat barito leaf extract on inflammatory cell infiltration (p = 0.200), angiogenesis (p = 0.067), and the number of goblet cells (p = 0.121) in the small intestine of mice induced by DSS. Value: Tabat barito leaf extract has no significant effect on inflammation induced by DSS in the small intestine of mice. This insignificant value can be caused by the small dose of tabat barito leaf extract and the characteristics of small intestine induced by DSS that are different from other tissues that have been previously studied.
Keyword: DSS, leaf extract, Inflammatory Bowel Disease.
DOI: https://doi.org/10.31838/ijpr/2020.12.01.130
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