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Antiinflammation Effect of Tabat Barito (Ficus deltoidea) Leaf Extract on Small Intestine of Mice Induced by Dextran Sodium Sulfate
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| Author:
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KUSMARDI KUSMARDI, RIZKY DINI FITRIYASA
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| Abstract:
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Purpose: To prove that tabat barito leaf extract has an anti-inflammatory effect on the small intestine of mice
induced by dextran sodium sulfate (DSS).
Methodology : This study used an experimental research method with DSS to induce colitis in mice. Mice
were then given tabat barito leaf extract with a concentration of 25% w / v and 50% w / v to compare with
mice given aspirin. Histopathological features of the small intestine mucosa are observed (hematoxylin-eosin
staining) to determine intestinal inflammatory variables including infiltration of inflammatory cells, angiogenesis,
and loss of goblet cells. Histopathological features were observed in 5 visual fields for each preparation.
Results: Statistical tests revealed that there was no significant effect of tabat barito leaf extract on
inflammatory cell infiltration (p = 0.200), angiogenesis (p = 0.067), and the number of goblet cells (p = 0.121) in
the small intestine of mice induced by DSS.
Value: Tabat barito leaf extract has no significant effect on inflammation induced by DSS in the small intestine
of mice. This insignificant value can be caused by the small dose of tabat barito leaf extract and the
characteristics of small intestine induced by DSS that are different from other tissues that have been previously
studied.
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| Keyword:
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DSS, leaf extract, Inflammatory Bowel Disease.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.01.130
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| Download:
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