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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Antihyperglycemic and anti-oxidative activities of Snakehead fish powder and Bitter melon extract in alloxan-induced diabetic mice

Author: TRI MULYANI, MUHTADI, WA ODE INDAH WULAN HARTINI HALIR, FAHRUN NUR ROSYID
Abstract: Purpose: Hyperglycemia can increase the ROS formation, which can deteriorate oxidative stress that, in turn, will cause damage to some constituent components of the lipid membrane later on forming malondialdehyde (MDA). Snakehead fish powder contains both albumin that is able to improve the damaged pancreatic beta cells for working well in reducing blood sugar and amino acid content that functions as antioxidants. Meanwhile, bitter melon is recognized to contain phenolic and flavonoid that acts as an antioxidant activity in normalizing free radicals causing oxidative stress. This study aims to test the ability of mix of Snakehead fish powder and bitter melon extract to reduce the levels of Malondialdehyde (MDA) in diabetic mice . Methodology: Male Wistar mice were divided into 5 groups, group (1) normal, (2) negative, (3) single dose of Snakehead fish powder 300 mg/kg.bw, (4) 150 mg/kg.bw bitter melon extract and (5) combination of Snakehead fish powder 300 mg/kg.bw and 150 mg/kg.bw bitter melon extract. The levels of mice MDA were measured at the time before treatment (after induction) and after the 10-day treatment. Statistical analysis used the normality test (Shapiro-Wilk), homogeneity test (Levene test), One Way parametric test, and Paired Sample T-test. Results: The results showed that all treatment groups were able to significantly reduce blood glucose and MDA levels (p<0.05) at a single dose of Snakehead fish powder 300 mg/kg.bw (0.378 µmol/mL), bitter melon extract 150 mg/kg.bw (0.425 µmol/mL) and a combination of Snakehead fish powder 300 mg/kg.bw and bitter melon extract 150 mg/kg.bw (0.397µmol/mL) when compared to the negative control.
Keyword: Snakehead fish, Bitter melon extract, MDA, Diabetes mellitus
DOI: https://doi.org/10.31838/ijpr/2020.12.01.128
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