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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Prevalence and Risk Factors of HBV, HCV, and HIV Infection in Thalassemia Patients Requiring Oral and Maxillofacial Care in an Iranian Sub-population

Author: EHSAN ALIABADI, SAEID TAVANAFAR
Abstract: Aim: Transfusion Transmitted viral Infections are still a significant burden in patients receiving blood products in developing countries. This study aimed to determine the prevalence and risk factors of hepatitis B, hepatitis C, and HIV infection in thalassemic patients approaching oral and maxillofacial department. Materials & Methods: An analytical, retrospective cohort study in thalassemic patients with a history of multiple transfusions was conducted, and the prevalence of hepatitis B, hepatitis C, and HIV infection and their risk factors from demographic, behavioral, and medical aspects were assessed. Results: A total of 202 male and female thalassemic patients with age above 19 years old were studied. The prevalence was 1.5% for HCV, 1% for HBV, and 0.5% for HIV. Major risk factors associated with these infections were: a history of unsafe drug injection abuse (83.3% in patients with TTI's vs. 2% in non-TTI patients), and history of sexual relationship with multiple partners (66.7% in patients with TTI's vs. 4.6% in non-TTI patients). Duration and frequency of transfusion was not a significant risk factor related to TTI. Conclusion: HCV infection was more frequently identified than HBV and HIV in thalassemic patients of this study. The present situation shows HIV to be the least prevalent infection. Clinical significance: Thalassemia patients might be more prone to blood transfusion-transmitted viral infections compared to the general population due to their regular blood transfusion requirements.
Keyword: AIDS, cohort study, HBV, HCV, HIV, Thalassemia
DOI: https://doi.org/10.31838/ijpr/2020.12.01.119
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