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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Study Preclinical Of Methanol Extract Of Melinjo (Gnetum gnemon, l.) Peel In Hyperuricemia Rat Model

Author: ARIFAH WAHYUNI, MUHAMMAD REZA NAJMI , AHMAD FAUZI
Abstract: This study aimed to measure the ability of melinjo peel to reduce uric acid levels of hyperuricemic rats. Twenty five (25) male rats divided into 5 groups: negative control that given by CMC-Na 1%, positive control (allopurinol 100 mg/kgBW), and group III-V given with methanol extract of melinjo peel (MEMP) with dose 50, 100, 200 mg/kgBW. Hyperuricemia rat of 25 male rats was induced with high purine diet twice daily for 4 days. Compstition of high purine diet used chicken liver juice with dose 2ml/200gBB. Uric acid level after dose 50,100 and 200 mg/kg BW intake in 7 day becoming normal with highest effect of reduce uric acid level in dose 200 mg/kg BW with ± 6.32 mg/dl compared than positive control allopurinol (p<0.05). The results showed that MEMP containing resveratrol and Gnetin C have the ability to reduce uric acid levels of hyperuricemia rat.
Keyword: Melinjo Peel, Gnetum gnemon, antihyperuricemia, resveratrol.
DOI: https://doi.org/10.31838/ijpr/2020.12.01.114
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0.12
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