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Study Preclinical Of Methanol Extract Of Melinjo (Gnetum gnemon, l.) Peel In Hyperuricemia Rat Model
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| Author:
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ARIFAH WAHYUNI, MUHAMMAD REZA NAJMI , AHMAD FAUZI
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| Abstract:
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This study aimed to measure the ability of melinjo peel to reduce uric acid levels of hyperuricemic rats.
Twenty five (25) male rats divided into 5 groups: negative control that given by CMC-Na 1%, positive control
(allopurinol 100 mg/kgBW), and group III-V given with methanol extract of melinjo peel (MEMP) with dose 50,
100, 200 mg/kgBW. Hyperuricemia rat of 25 male rats was induced with high purine diet twice daily for 4 days.
Compstition of high purine diet used chicken liver juice with dose 2ml/200gBB. Uric acid level after dose
50,100 and 200 mg/kg BW intake in 7 day becoming normal with highest effect of reduce uric acid level in dose
200 mg/kg BW with ± 6.32 mg/dl compared than positive control allopurinol (p<0.05). The results showed
that MEMP containing resveratrol and Gnetin C have the ability to reduce uric acid levels of hyperuricemia rat.
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| Keyword:
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Melinjo Peel, Gnetum gnemon, antihyperuricemia, resveratrol.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.01.114
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| Download:
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