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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Hermit’s Water Lily (Limnocharis Flava) Extract: A Potential Anti-Inflammatory Agent with Minimal Ulcerogenic Toxicity on Stomach

Author: TANTI SUJONO, GALANG ADI WIBOWO, ZAKKY CHOLISOH
Abstract: Hermit’s water lily (Limnocharis flava) is a plant that grows in Southeast Asia. This plant has the potential to be used as an anti-inflammatory medication, so this study was conducted with the aim of evaluating its phytochemical profile qualitatively and then evaluating the anti-inflammatory activity of its ethanolic extract in formaline induced male Wistar rats. This study also evaluated the toxicity of Limnocharis flava leaves ethanol extract on the stomach and kidneys. Rats were induced subplantar on the soles of the paws with 2% formalin on day 1 and day 3, then treated with ethanol extracts of Hermit's water lily leaves at a dose of 10 and 50 mg / kg body weight for 6 days. Diclofenac Na 10 mg / KgBW was used as a positive control. Measurement of the rat’s paw thickness with calipers to obtain data on oedema (inflammation) inhibition was carried out every day. Statistical analysis showed that the ethanolic extract of Hermit's water lily leaves contained flavonoids, tannins, and saponins. The ethanolic extract of Hermit's water lily leaves showed anti-inflammatory effect which was not significantly different from diclofenac Na. Histopathological examination results on the stomach and kidneys clearly indicate that the ethanolic extract of Hermit's water lily leaves has minimal adverse effects on the stomach, while the adverse effects on the kidneys are equivalent to positive control.
Keyword: anti-inflammatory, Limnocharis flava, stomach toxicity, kidney toxicity.
DOI: https://doi.org/10.31838/ijpr/2020.12.01.110
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