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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Correlation between ABO Groups with Viral Load in Chronic Hepatitis B Infection

Author: MALIHEH METANAT, ALIREZA ANSARI-MOGHADAM , SAEED JAVDANSIRAT
Abstract: Background: Given the high prevalence of chronic hepatitis B, and identifying factors affecting the severity of the disease, including the relationship between blood levels of virus (viral load) is important. Accordingly, we aimed to evaluate the relationship of hepatitis B viral load with blood groups. Methods: In this cross-sectional study, we enrolled sample volume of 206 patients of chronic hepatitis B aged above 14 years during 2015-2016 in Zahedan. The sampling method was convenient sampling. Exclusion criteria were immunodeficiency disorders, treatment with anti-viral drugs, or other causes of hepatitis. Viral load was determined using RT-PCR. We classified patients based on viral load to three groups which included less than 2000 IU/ml, 2000 to 2000-10 IU/ml. The frequency of blood groups in every group was compared separately and the relationship between blood group and viral load based on gender was evaluated. All the data analysis performed using SPSS version 20 software and Kruskal-Wallis test. Results:In this study, the number of 206 chronic hepatitis B patients that participated had 135 men and 71 women. 75 patients (36%) had blood group O as the most common blood group type, and blood groups A, B and AB were 67(30%), 35(26%) and 9(6%) respectively. The most common blood group in men was A and in women was O. The relationship between viral load with blood group type in three groups was as follows: in the group with viral load less than 2000 IU/ml and 2000 to 2000-10 6 IU/ml and more than 10 6 IU/ml, the blood group was type O, and in the group with viral load of more than 10 6 IU/ml, the blood group type A was most common. The difference between blood groups was not statistically significant (p=0.916). Almost 65% of patients with blood group types of O and B had viral loads less than 2000 IU/ml. Conclusion: The order of most common blood group type of patients of the study were O, A, B and AB respectively, which was matched with the prevalence in the population. We noted no statistically significant difference between types of blood groups and viral load in the three groups. In addition, a smaller percentage of patients with blood group B and AB showed high viral loads more than 2000 IU/ml.
Keyword: Hepatitis B, Viral load, ABO blood groups
DOI: https://doi.org/10.31838/ijpr/2020.12.01.105
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