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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Anti-Hypercholesterolemic Activity of Ethnolic Extract of Gomphrena globosa Flowers and its Phytochemical Screening

Author: AULIA RAHMAN, TANTI AZIZAH SUNJONO
Abstract: Objective: To determine the antihypercholesterol activity of ethanolic extract of Gomphrena globosa flowers and to know the compound that contained in ethanolic extract of G. globosa (EEGg). Methods: This research is experimental research with pre and post randomized controlled group design methods. Thirty rats were divided into six groups, i.e. positive control (simvastatin), negative control (CMC), normal control, and groups of EEGg, which were given dose of 125, 250, and 500 mg/kg.bw, respectively. All groups except normal group were given hypercholesterol diet for 30 days until rats passed hypercholesterolemia. These diet contained margarine, used-cooking oil, quail eggs, and salted yolks. After test animals become hypercholesterolemia, rats were given treatment for 14 days while still being given a high diet in cholesterol. Cholesterol level was measured by CHOD-PAP method using UV-Vis spectrophotometer. Result: EEGg reduced cholesterol (significant difference compare to negative control). The level of cholesterol in EEGg dose of 125, 250, and 500 mg/kg.bw was decreased by 12.11, 24.03, and 25.32%, respectively. The result of screening phytochemical showed that EEGg had some secondary metabolites such as saponin, alkaloid, flavonoid, and steroid.
Keyword: Hypercholesterolemia, Gomphrena globosa, phytochemical screening, diet hypercholesterol
DOI: https://doi.org/10.31838/ijpr/2020.12.01.101
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0.12
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