|
Anti-Hypercholesterolemic Activity of Ethnolic Extract of Gomphrena globosa Flowers and its Phytochemical Screening
|
|
| Author:
|
AULIA RAHMAN, TANTI AZIZAH SUNJONO
|
| Abstract:
|
Objective: To determine the antihypercholesterol activity of ethanolic extract of Gomphrena globosa flowers
and to know the compound that contained in ethanolic extract of G. globosa (EEGg).
Methods: This research is experimental research with pre and post randomized controlled group design
methods. Thirty rats were divided into six groups, i.e. positive control (simvastatin), negative control (CMC),
normal control, and groups of EEGg, which were given dose of 125, 250, and 500 mg/kg.bw, respectively. All
groups except normal group were given hypercholesterol diet for 30 days until rats passed hypercholesterolemia.
These diet contained margarine, used-cooking oil, quail eggs, and salted yolks. After test animals become
hypercholesterolemia, rats were given treatment for 14 days while still being given a high diet in cholesterol.
Cholesterol level was measured by CHOD-PAP method using UV-Vis spectrophotometer. Result: EEGg reduced
cholesterol (significant difference compare to negative control). The level of cholesterol in EEGg dose of 125,
250, and 500 mg/kg.bw was decreased by 12.11, 24.03, and 25.32%, respectively. The result of screening
phytochemical showed that EEGg had some secondary metabolites such as saponin, alkaloid, flavonoid, and
steroid.
|
| Keyword:
|
Hypercholesterolemia, Gomphrena globosa, phytochemical screening, diet hypercholesterol
|
| EOI:
|
-
|
| DOI:
|
https://doi.org/10.31838/ijpr/2020.12.01.101
|
| Download:
|
Request For Article
|
|
|