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Crystal Growth and Structural Refinement of Chlorzoxazone (5-Chloro -3H-benzooxazol-2 2-one): An Effective Muscle Relaxant
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| Author:
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RANJANA SHARMA, DIXIT PRASHER DIXIT PRASHER, R. K. TIWARI
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| Abstract:
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The title compound, chlorzoxazone has a good medicinal interest in the treatment of painful musculoskeletal
conditions and is also used to inhibit allergic rhinitis and asthma. In
crystal structure interpretation of chlorzoxazone were carried out by operating single X
The structural refinement was done by using SHELXS 97 program. It was observed that the cry
chlorzoxazone undergoes in space group P
= 9.0202(5) ?, c = 10.0463(5) ?, a = 93.435 (4)0,
calculated density is 1.658 Mg m-3. The value for structure factor was 172 and final R = 0
reflections.
The title compound, chlorzoxazone has a good medicinal interest in the treatment of painful musculoskeletal
the present study, the molecular as well as the
ray diffraction technique.
The title compound, chlorzoxazone has a good medicinal interest in the treatment of painful musculoskeletal
conditions and is also used to inhibit allergic rhinitis and asthma. In the present study, the molecular as well as the
crystal structure interpretation of chlorzoxazone were carried out by operating single X-ray diffraction technique.
was done by using SHELXS 97 program. It was observed that the cry
chlorzoxazone undergoes in space group P-1 with triclinic crystal system1. The unit cell dimensions a = 3.8166(2)
= 93.435 (4)0, ß = 95.507(3)0, ?= 98.373 (4)0, V= 339.6(3) Å3, and z=2;
3. The value for structure factor was 172 and final R = 0.0312 for 1209 unique
was done by using SHELXS 97 program. It was observed that the crystallization of
1 with triclinic crystal system1. The unit cell dimensions a = 3.8166(2) ?, b
= 98.373 (4)0, V= 339.6(3) Å3, and z=2;
.0312 for 1209 unique
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| Keyword:
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chlorzoxazone ;muscle relaxant drug;crystal structure;x-ray diffraction
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.01.071
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| Download:
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