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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Drug Utilization in HF Patients: Exploring Reasons to Improve Adherence at Tertiary Care Unit

Author: KAVITA BANSAL, SATYENDRA KUMAR RAJPUT, VINOD SHARMA, V. S. MATHUR
Abstract: The objective of this study is to analyze prescribing behavior of heart failure (HF) drugs and identify socioeconomic factors affecting the medication adherence .Our study includes 90 HF patients with average age 59.4 ± 11.38 (34-80) years.The average heart rate (HR) of HF patients was86.02 ± 15.2 (52-112) and average ejection fraction (EF) was 34.49 ± 8.11 (20-65). The mean number of days spent by an HF patient in hospital was 4.72 days (95%CI: 4.41 - 5.04).The patients with heart failure with reduced ejection fraction (HFrEF) were mainly prescribed withACEinhibitors (76.67%), ARBs (42.22%), Diuretics (68.89%), and Beta-blockers (54.44%). Other drug categories prescribed included Antiplatelets (41.11%), Anticoagulants (21.11%), Calcium channel blockers (31.11%), andInotropic agents (24.44%).ACE-inhibitors and Diuretics were most popular drug categories withRamipril (C09AA05) and Furosemide(C03CA01) being most frequently prescribed drugs, respectively. On average,15.28 drugs/patient (95%CI: 14.94 -15.62) were prescribed whereas, averageprescribed cardiovascular drugs/patient were only 8.24 (95%CI: 7.89 - 8.59). Poly-pharmacy was observed in 88.89% patients.According to thestudy dataset, a total of 1375 drugs were prescribed to 90 subjects,of which 76.0% were given throughoral route and remaining24.0% through non-oral routeincluding parenteral route (intramuscular (IM) and intravenous (IV)) and inhalational route. Charlson Comorbidity Index (CCI)was calculated to estimate the 10-year survival rate. ACEI and Diuretics therapy were considered as adherence indicators for HF medication over follow-up of 12 months and adherencerate was 74.44% and 78.88%, respectively.
Keyword: Heart Failure, Charlson Comorbidity Index,Poly Pharmacy,Adherence, Medication
DOI: https://doi.org/10.31838/ijpr/2020.12.01.063
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