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Study effect of sulfur containing amino acid supplementation on oxidative stress, inflammatory markers and serum lipid in relation to obese subjects
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| Author:
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FALAH SHARI, ANWAR YONIS IBRAHIM, JUBRAN K. HASSAN, H. N. K. AL-SALMAN
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| Abstract:
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Obesity is a medical condition caused by an imbalance between energy intake and energy expenditure. Obesity is a
state of low-grade chronic inflammation .Taurine is a sulfur-containing amino acid mainly obtained from diet, that is
present in mammalian tissues in millimolar concentrations . Taurine has the main biological actions as potent
antioxidant and anti-inflammatory, xenobiotic conjugate , regulate blood pressure ,osmoregulation,cell membrane
stabilizer. Some researchers found decreased levels of plasma taurine in obese subjects and the effects of taurine on
the on the progression of obesity in animal models and humans and the anti-obesity agent.The present study was
designed to investigate whether taurine supplementation suppress oxidative stress, inflammatory response and to
modulate glucose homestasis and improvement lipid metabolism in obese subjects.A randomized double blind
placebo –controlled study was carried out in Basrah governorate, southern Iraq. Fifty obese subjects (20 males and
30 females) with amean age (37.86±4.39 ) were recruited from Basrah hospital in Basrah governorate from 20
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November 2017 to25
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April 2018. Twenty five of those obese individuals received taurine supplementation as capsule
(1gm 3 times daily ,others twenty five obese subjects were matched by age and body mass index and randomly
assigned to either the placebo(which was identical in appearance to taurine capsule ) resistance starch 1gm 3 times
daily, The study lasted 8weeks, After blood samples were collected for laboratory measurement of biochemical
parameters: Random blood glucose(RBS), HbA1c, lipid profile ( serum total cholesterol (s.TC), serum triglyceride
(s.TG) , HDL-C , inflammatory marker (IL-1 , IL-6, MDA,TNF-a).Both the placebo and taurine groups show
significant reduction in weight and BMI (<0.0001) and significant reduction in lipid profile (?s.TC, ?s.TG , ?HDL-c
<0.0001) ,reduction in blood sugar RBS ,HbA1c <0.001, significant reduction in inflammatory marker IL-6 <0.001 ,
oxidative stress MDA <0.0001 with no difference between taurine and placebo regarding to IL-1, TNFa.Taurineameliorte
obesity through stimulation of energy expenditure ,modulation of lipid metabolism, down
regulates the production of pro-inflammatory and anti-oxidative stress,regulate blood sugar.
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| Keyword:
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glucose homestasis ,Basrah governorate.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.01.062
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| Download:
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Request For Article
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