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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Study effect of sulfur containing amino acid supplementation on oxidative stress, inflammatory markers and serum lipid in relation to obese subjects

Author: FALAH SHARI, ANWAR YONIS IBRAHIM, JUBRAN K. HASSAN, H. N. K. AL-SALMAN
Abstract: Obesity is a medical condition caused by an imbalance between energy intake and energy expenditure. Obesity is a state of low-grade chronic inflammation .Taurine is a sulfur-containing amino acid mainly obtained from diet, that is present in mammalian tissues in millimolar concentrations . Taurine has the main biological actions as potent antioxidant and anti-inflammatory, xenobiotic conjugate , regulate blood pressure ,osmoregulation,cell membrane stabilizer. Some researchers found decreased levels of plasma taurine in obese subjects and the effects of taurine on the on the progression of obesity in animal models and humans and the anti-obesity agent.The present study was designed to investigate whether taurine supplementation suppress oxidative stress, inflammatory response and to modulate glucose homestasis and improvement lipid metabolism in obese subjects.A randomized double blind placebo –controlled study was carried out in Basrah governorate, southern Iraq. Fifty obese subjects (20 males and 30 females) with amean age (37.86±4.39 ) were recruited from Basrah hospital in Basrah governorate from 20 th November 2017 to25 th April 2018. Twenty five of those obese individuals received taurine supplementation as capsule (1gm 3 times daily ,others twenty five obese subjects were matched by age and body mass index and randomly assigned to either the placebo(which was identical in appearance to taurine capsule ) resistance starch 1gm 3 times daily, The study lasted 8weeks, After blood samples were collected for laboratory measurement of biochemical parameters: Random blood glucose(RBS), HbA1c, lipid profile ( serum total cholesterol (s.TC), serum triglyceride (s.TG) , HDL-C , inflammatory marker (IL-1 , IL-6, MDA,TNF-a).Both the placebo and taurine groups show significant reduction in weight and BMI (<0.0001) and significant reduction in lipid profile (?s.TC, ?s.TG , ?HDL-c <0.0001) ,reduction in blood sugar RBS ,HbA1c <0.001, significant reduction in inflammatory marker IL-6 <0.001 , oxidative stress MDA <0.0001 with no difference between taurine and placebo regarding to IL-1, TNFa.Taurineameliorte obesity through stimulation of energy expenditure ,modulation of lipid metabolism, down regulates the production of pro-inflammatory and anti-oxidative stress,regulate blood sugar.
Keyword: glucose homestasis ,Basrah governorate.
DOI: https://doi.org/10.31838/ijpr/2020.12.01.062
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