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Spectrophotometric Determination of Candesartan Cilexetil and Atenolol In Pure and Pharmaceutical Forms
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| Author:
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SURA L.ALKHAFAJI, RAJWAN A. ALAZAWY, ABDULBARI MAHDI MAHOOD
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| Abstract:
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The present work aimed to estimate two antihypertensive drugscontent using the proposed analytical UV-
Spectrophotometric methods. The two antihypertensive drugs; candesartan cilexetil(CAN) and Atenolol (ATE) were
estimated in pure form and pharmaceutical tablets. Firstly, using different blanks for each drug composed of
methanol: distilled water (8:2) and 0.1M hydrochloric acid HCl were applied and scanned at specific wavelengths (?
max) of 254 nm and of 224 nm for Candesartan cilexetil and Atenolol, respectively. The methods were confirmed for
linearity through preparation a series of certain concentration and measure their absorptions and correlation
coefficient, and then these methods were validated by studying the accuracy and precision. The linearity and relative
standard deviation RSD% for candesartan cilexetil and atenolol were (5-60)µg/ml, (3-40) µg/ml, (0.4-2.46) and (0.480.74),
respectively.
The
relative
error
RE%
for
candesartan
cilexetil
and
atenolol
were
(0.26-1.07)
and
(0.33-1.6).The
percentage
of
recoveries
were
found
to
be
in
the
range
of
98.9%-101%
and
98.4-99.6%
for
candesartan
cilexetil
and
atenolol,
respectively.
Validation
experiments
were
also
accomplished
to
reveal
the
low
limit
of
detection
LOD,
and
limit
of
quantification
LOQ
for
candesartan
cilexetil
and
atenolol
and
were
found
to
be
(0.14)
(0.09)
and
LOQ
(0.48)
(0.3),
respectively.
Hence,
the
simple,
accurate
methods
can
be
used
for
routine
analysis
of
candesartan
cilexetil
and
atenolol
in
bulk,
and
their
pharmaceutical
tablets
form.
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| Keyword:
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Candesartan Cilexetil, Atenolol, Antihypertensive drugs, UV- Spectroscopy.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.01.059
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| Download:
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