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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Spectrophotometric Determination of Candesartan Cilexetil and Atenolol In Pure and Pharmaceutical Forms

Author: SURA L.ALKHAFAJI, RAJWAN A. ALAZAWY, ABDULBARI MAHDI MAHOOD
Abstract: The present work aimed to estimate two antihypertensive drugscontent using the proposed analytical UV- Spectrophotometric methods. The two antihypertensive drugs; candesartan cilexetil(CAN) and Atenolol (ATE) were estimated in pure form and pharmaceutical tablets. Firstly, using different blanks for each drug composed of methanol: distilled water (8:2) and 0.1M hydrochloric acid HCl were applied and scanned at specific wavelengths (? max) of 254 nm and of 224 nm for Candesartan cilexetil and Atenolol, respectively. The methods were confirmed for linearity through preparation a series of certain concentration and measure their absorptions and correlation coefficient, and then these methods were validated by studying the accuracy and precision. The linearity and relative standard deviation RSD% for candesartan cilexetil and atenolol were (5-60)µg/ml, (3-40) µg/ml, (0.4-2.46) and (0.480.74), respectively. The relative error RE% for candesartan cilexetil and atenolol were (0.26-1.07) and (0.33-1.6).The percentage of recoveries were found to be in the range of 98.9%-101% and 98.4-99.6% for candesartan cilexetil and atenolol, respectively. Validation experiments were also accomplished to reveal the low limit of detection LOD, and limit of quantification LOQ for candesartan cilexetil and atenolol and were found to be (0.14) (0.09) and LOQ (0.48) (0.3), respectively. Hence, the simple, accurate methods can be used for routine analysis of candesartan cilexetil and atenolol in bulk, and their pharmaceutical tablets form.
Keyword: Candesartan Cilexetil, Atenolol, Antihypertensive drugs, UV- Spectroscopy.
DOI: https://doi.org/10.31838/ijpr/2020.12.01.059
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