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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Synthesis and characterization of some heterocyclic compounds derivative of some chalconeswith Evaluation for Antibacterial Activity for Some of them.

Author: DHAMER. M, AYAD. SULAIMAN., IBTISAM .KHALIFA.
Abstract: Quinoxalines subsidiaries combination of Benzene-1,2-diamine was responded with oxalic corrosive to shape 1,4,4a,8a-tetrahydroquinoxaline-2,3-dion was chlorinated by utilizing Phosphorous oxytrichloride in (dmf), to frame 2, 3-dichloro-4a,8a-dihydroquinoxaline. This dichloro-4a,8a-dihydroquinoxaline compound exposed to response with 4 amino acetophenone in DMF and sodium carbonate(anhydrous) "reflexes, for 5 (h) to frame" 1-(4(3chloroquinoxalin,-2-yl) amino) ethanan-1-one. Additionally "1(3-chloroquinoxalin-2-yl), amino)phenyl) ethanan-1-one" at that point responded with relating fragrant aldehydes to frame quinoxalinechalcone by claisen Schmidt response. At that point response this quinoxalinechalcone with (hydrazine hydrate, phenyl hydrazine , thiourea , urea , thiosemicarbazide ) readiness quinoxalinechalcone subordinates. Every one of the mixes were described by IR, 1H NMR
Keyword: Quinoxaline, dimethyl foramide (DMF), IR, 1H NMR, chalcone,
DOI: https://doi.org/10.31838/ijpr/2020.12.01.057
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0.12
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