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Effect of the Total Lycium barbarum Carotene on Normal Human Blood Lymphocytes
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| Author:
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AHMED ABDULLAH, ZAINAB YASEEN MOHAMMED HASAN , KHULOOD.W.ALSAMMARRAIE
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| Abstract:
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The pioneering and recognition of novel medications, that increase the ability of the immune system tasks has
become a very crucial target for the Immune-pharmacology researches as well as for the Onco-therapist. Our
scientific work demonstrated the favorable effects of Iraqi wild type Lycium barbarum active components as an
immunomodulating agent. The immune stimulating effect of the extracted total carotene notified by the
proliferation of the normal blood lymphocytes, which estimated by the MTT assay and the alterations of IL-10 and
TNF-a levels that evaluated by ELISA technique. The elevations of those two cytokines have been demonstrated
after 2 and 4 hours exposure of the extract at concentrations (125 and 250µg/ml). The results of the present study
indicated that Lycium barbarum Carotenoids can behave as an immunostimulant, acted to promote IL-10
production and increase up to four folds TNF-a level especially after 2 hours exposure and at a lower
concentration (125µg/ml)
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| Keyword:
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Lycium barbarum carotene, Immunomodulation, IL-10, TNF-a Elisa assay, MTT assay.
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| EOI:
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| DOI:
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| Download:
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