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A Modified and Credible Methods to Estimate NitrofurantoinIn theStandard of Substances and Pharmaceutical Dosage
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| Author:
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KHAWLA ABD, QUTAIBA A. QASIM, GHASSAN SALAH AHMED, H. N. K. AL-SALMAN
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| Abstract:
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For identifying the nitrofurantoin drug, the four selective, sensitive and simple methods were
developed. And these methods are then proved as well as validated in our particular research
work. These methods are dependent of the nitrofurantoin reactions, performed by utilizing
ZN/Cl, as well as iron mixture (II)and neutral medium is used for ferric chloride reduction
through this drug along with 1, method A- 10- phenanthroline or 2, method B- bisperdyl or blue
chromogen is formed when this particular drug binds with the oxidized ferric chloride and
potassium ferritic cyanide reagent(method D). A colourful product is produced with the
ninhydrin and nitrofurantoin reagent interaction and also method D is also dependent on this. By
using method A, B, C and D the measurement of resulted red chromosomes is found to 500nm,
515nm, 735nm, and 575nmrespectively.Method A, B, C and D uses the concentration ranges of
0.20-8.0 mg/ml 0.25-40 mg/ml, 0.50-30 mg/ml and 0.50-50 mg/ml respectively and in such optimal
conditionsBers law is applied along with molar’s absorption values are also estimated.The
statistical comparability of the suggested methods resulted with all those acquired by the
reference technique which proved outstanding agreement as well as also shown there does not
exist any interference through typical excipients in pharmaceutical formulations.
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| Keyword:
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Chelating agents, Ferric chloride, Nitrofurination drug.
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| EOI:
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| DOI:
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