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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Tramadol: Clinical Applications, Psychological effects and Toxicity

Author: RAZIE EGHTESADI, SOMAYE SAFAVI, NEDA VAHED, SARA AZADI, ALI KEYHANI, MORAD RASOULI-AZAD, AMIR GHADERI
Abstract: Tramadol is considered opioid-like analgesic with serotonin and monoamine reuptake inhibition property. This drug is used worldwide and is listed in many medical guidelines for pain management. Tramadol because of monoaminergic activities and opioidergic,has long been used as a well tolerated alternative to other drugs in moderate pain. Also, tramadol has less effect on the respiratory center than morphine and tends to control pain better on movement than morphine. Also, this drug when inject has less abuse potential. It produces analgesic action by exhibiting central serotonergic receptors, gamma-aminobutyric acid (GABA) catecholamine, and agonistic activity to mu-opioid receptor. Long-term use of high doses of this drug may be link to physical dependence and withdrawal syndrome; it is also possible that it can cause mental health disorders. Tramadol have several adverse effects, so the tramadol must choose carefully for pain management. There are a few evidence of seizure induced by tramadol at therapeutic dose. In addition, subjects with medical history of illicit drug abuse, seizure, alcoholism, epilepsy, head injury and metabolic disturbance have more possibility of seizures when treated with tramadol. The purpose of this review is to evaluate tramadol drug, clinical applications, complications, physiological and psychological effects, toxicity and toxicity.
Keyword: Tramadol, Clinical Applications, Psychological effects, Poisoning, Toxicity
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