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The Effect of Rosella (Hibiscus sabdariffa Linn) on Insulin Resistance in Patients with Type 2 Diabetes Mellitus: A Randomized Clinical Trial
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| Author:
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DWI SARBINI, EMY HURIYATI , HAMIM SADEWA , MAE SRI HARTATI WAHYUNINGSIH
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| Abstract:
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Insulin resistance in Type 2 Diabetes Mellitus (T2DM) is indicated with high fasting blood glucose level, fasting
insulin and HOMA-IR. The long-time consume of diabetes drugs would bring harm. Rosella can be used as a
complementary drug to improve insulin resistance and prevent T2DM complications. This study seeks the effect of
consuming Rosella on fasting blood glucose, fasting insulin and HOMA-IR in T2DM patients.
The study design used double-blinded & placebo-controlled randomized clinical trial with intervention (placebo and
Rosella) for 8 weeks. The sample consisted of 52 T2DM outpatients at Health Office Yogyakarta City.
Measurement of fasting blood glucose was conducted through GOD-PAP method, fasting insulin was measured by
MEIA, HOMA-IR was calculated with HOMA Calculator 2.2.3 Version. Analysis of the influence of Rosella on
fasting blood glucose, fasting insulin and HOMA-IR level in one group were tested with the Wilcoxon Signed Test
and the effect between groups were tested through Mann Whitney with a significance level of 95%.
Rosella consumption can reduce fasting blood glucose, fasting insulin and HOMA-IR levels. There was a significant
effect of Rosella administration on decreasing fasting blood glucose level in T2DM patients (p=0.001) but there
were no significant effect on decreasing fasting plasma insulin level and HOMA-IR levels (p=0.932 and p=0.368).
Rosella can improve insulin resistance by reducing fasting blood glucose levels, fasting insulin levels and HOMA-IR
values.
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| Keyword:
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type 2 diabetes mellitus, glucose, Hibiscus sabdariffa Linn, HOMA-IR, insulin, Rosella
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| EOI:
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| DOI:
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