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Model Predictive Control based Closed Loop Drug Infusion Device in Critical Care setups using computational therapeutics – A Modelling and Simulation Study
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| Author:
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CHANDRAMOULI R, D SATHYANARAYANA, RAMAN DANG, RANGANATH MUTHU, R.MURALI
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| Abstract:
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Aim: Managing the vital parameters in patients recuperating in critical care setups is a routine activity.
Hypertensive emergencies are common in critical care patient’s post-surgical intervention. Mean Arterial
Pressure (MAP) is an essential parameter continually monitored in and has to be maintained in a set
physiological value to maintain adequate perfusion to end organs.
Material & Methods:
Sodium nitroprusside (SNP) is a potent vasoactive drug which is used in interventional cardiology to manage
hypertensive emergencies. SNP is administered through intravenous route as an infusion which is difficult to
regulate manually. Hence many workers have adopted elements of control engineering to regulate the rate and
extent of many hard to infuse drugs by building closed loop drug infusion devices (CL-DIS) powered by many
control engineering algorithms like fuzzy logic, artificial neural networks, Proportional Resonance Controller
and Fractional Order Proportional Integral Derivative Controller to regulate the infusion. In this work an
attempt to conceptualize model and simulate a CL-DIS using a Model Predicative Controller (MPC) is
implemented.
Results & Discussion:
MPC based CL-DIS is modelled and simulated in this work. This is compared against the other popular control
engineering algorithms of Proportional Resonance Controller and Fractional Order Proportional Integral
Derivative controller and their performance characteristics of peak overshoot, rising response time, settling
time, peak response time and noise variation was compared.
Conclusion:
MPC based CL-DIS has the potential to regulate the infusion of potent vasoactive drug and is capable of doing
adaptive controlled drug delivery based on the feedback controller and is capable of operating within
constrained set of physiological MAP values between 60 and 70 mm Hg
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| Keyword:
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losed Loop Drug Infusion system, SNP, MPC, FOPID, PRC
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| EOI:
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| DOI:
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