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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Assessment of Serum Interleukin-6 and Leptin Levels in Postmenopausal Iraqi Women

Author: MAHDI H.HUMMADI, HIBA S.AHMED, ZAINABS.HUSSIEN, ZINAHS.ALI
Abstract: Menopause is the perpetual termination of menstruation owed to defeat of ovarian follicular activity. Menopause in women leads to various physiological changes in the body. To evaluate serum interleukin-6 and leptin levels in postmenopausal women and equated them with premenopausal women. Forty five postmenopausal women were participated in this work and compared them with 45 premenopausal women who had a regular menstruation. They were attending the Medical City Hospital/Obstetrics and Gynecology Department during the period from March 2019 until the end of August2019. Anthropometric and clinical parameters were taken for all individuals. In this study, there was a significant increase (p =0.05 )in fasting serum glucose, serum total cholesterol, triacylglycerol, low density lipoprotein cholesterol, and leptinin postmenopausal group as paralleled to premenopausal group. There was a decrease in serum estradiol in postmenopausal women as paralleled to premenopausal women, but it was not significant. Additionally, there was a substantialreduction in serum progesterone while, there was a significant rise in serum interleukin-6 in postmenopausal women as paralleled to premenopausal women. This work shows the changes of estradiol, progesterone, and leptin levels in the postmenopausal women. Additionally, an elevation in IL6 level due to the presence of inflammation in those women
Keyword: Postmenopause, Interleukin-6, Leptin
DOI: https://doi.org/10.31838/ijpr/2020.12.01.054
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