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Synthesis of Some New Schiff Bases Starting from 2,2 Dimorpholinyl Acetic Acid and Evaluating the Biological activity
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| Author:
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SALEEM S., EMAN M. HUSSAIN
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| Abstract:
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In this study new derivatives of Schiff bases
(5-10
) were synthesized from the new starting material 1 . Which has
been synthesized by the reaction of
(1 mol.
)of dichloroacetic acid with two moles of morpholine, in the presence of
potassium hydroxide, Ester derivatives 2 and 3 were synthesized by the reaction of 1 with methanol or ethanol
respectively in the presence of sulphuric acid as catalyst . Compound 2 was also prepared from dimethylsulphate with
high yield , 2 and 3 was used to synthesized 2,2-dimorpholinylacetohydrazide 4 via reaction with NH2NH2.H2O 80%
.Imines
(5-10
) were synthesized via the reaction of 4 with appropriate aromatic aldehydes in the presence of G.A.A
as a catalyst . Derivatives compounds
(1-10
) were identified by FT-IR and some of them by
1
H-NMR and mass
spectroscopy . The biological activity of new derivatives
(5-10
) was examined against two kinds of bacteria E. coli
(G-
),
Staph. aureus (G+
). Some of these compounds was found to be vital activity against the selected bacteria.
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| Keyword:
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Morpholine, Dichloroacetic acid, Acid hydrazide, Schiff bases, biological activity.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.01.048
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| Download:
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Request For Article
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