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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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Impact of an External and Internal factors of overweight and obesity in urban
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Synthesis of Some New Schiff Bases Starting from 2,2 Dimorpholinyl Acetic Acid and Evaluating the Biological activity

Author: SALEEM S., EMAN M. HUSSAIN
Abstract: In this study new derivatives of Schiff bases (5-10 ) were synthesized from the new starting material 1 . Which has been synthesized by the reaction of (1 mol. )of dichloroacetic acid with two moles of morpholine, in the presence of potassium hydroxide, Ester derivatives 2 and 3 were synthesized by the reaction of 1 with methanol or ethanol respectively in the presence of sulphuric acid as catalyst . Compound 2 was also prepared from dimethylsulphate with high yield , 2 and 3 was used to synthesized 2,2-dimorpholinylacetohydrazide 4 via reaction with NH2NH2.H2O 80% .Imines (5-10 ) were synthesized via the reaction of 4 with appropriate aromatic aldehydes in the presence of G.A.A as a catalyst . Derivatives compounds (1-10 ) were identified by FT-IR and some of them by 1 H-NMR and mass spectroscopy . The biological activity of new derivatives (5-10 ) was examined against two kinds of bacteria E. coli (G- ), Staph. aureus (G+ ). Some of these compounds was found to be vital activity against the selected bacteria.
Keyword: Morpholine, Dichloroacetic acid, Acid hydrazide, Schiff bases, biological activity.
DOI: https://doi.org/10.31838/ijpr/2020.12.01.048
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