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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Synthesis and Antioxidant Study of new1,3Oxazepin-4,7-dione and1,2,3-Triazole derivatives

Author: HAWRAA MAZYED, RIYADH J. NAHI
Abstract: A series of new heterocyclic compounds containing 1,3-oxazepinering system wassynthesized by a cycloaddition reaction of Schiff bases with maleic and phthalic anhydrides.Additionally, two new compounds containing 1,2,3-triazole ring system and the bioactive benzene sulfonic acid moiety were designed and synthesized via 1,3-dipolarcycloaddition reaction of 4-azidobenzene sulfonic acid with propiolic acid andacetylacetone. The structure of all the target compounds was confirmed by FT-IT, 1H-NMR, 13C-NMR and mass spectroscopies. Furthermore, the antioxidant activity studyshowed that all the target compounds have a promising antioxidant activity against DPPH
Keyword: Heterocyclic Chemistry, Schiff base, 1,3-Oxazepine, 1,2,3-Triazole, Antioxidant activity, DPPH
DOI: https://doi.org/10.31838/ijpr/2020.12.01.047
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0.12
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