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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Spectrophotometric Method for Determination of Ranitidine hydrochloride in Pharmaceutical Formulations using Cobalt Thiocyanate as Chromogenic Reagent after Cloud Point Extraction

Author: AZHAR GHALI
Abstract: To benefit fromcobalt thiocyanatere agent and cloud pointextraction procedure to improvement of spectrophotometric technique that used for evaluation of ranitidine HCL in pure substance and pharmaceutical formulations. The coloredsubstance isproduced by the reaction of the amine group of drug with cobalt thiocyanatemetal, which is prepared intoTritonX-114 (non-ionic surfactant )from a watery liquid. Dilution of the surfactant-rich phase was done by ethanol while the measurement of the absorption was done by spectrophotometer at (620 )nm. The study determined the influence of many parameters such as Triton X-114 level, pH, time and temperature of the cloud point. Using the calibration graph for showing the range (0.1-10 )µg mL -1 of ranitidine HCL with (regression 2 )r =0.9996. For information, the relative standard deviation was (0.6581 ), and the preconcentration factor was (20 ). The suggested technique was used for the estimation of ranitidine HClin pharmaceutical formulations (tablets). The study validates the tested methods with the spectrophotometer.
Keyword: Cloud point extraction; ranitidine HCl; Spectrophotometry; Triton X-114; Cobalt thiocyanate; Pharmaceutical formulations
DOI: https://doi.org/10.31838/ijpr/2020.12.01.043
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