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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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The therapeutic effect of the active compound derived from green tea on induced infection of Entamoebahistolytica in mice

Author: SURA ABDULATEEF, HASANA. AAL OWAIF , MANHAL F. AHMED
Abstract: Entamoebahistolytica is the causative parasite of amoebiasisthat mainly occurring in tropical regions. The present study showed the therapeutic effect of the caffeine extracted from the green tea on the laboratory mice that experimentally infected by E. histolytica. A total of 52 samples of stool were collected from the Child’s Central Teaching Hospital and Al-Yarmouk Teaching Hospital in Baghdad city, and then E. histolytica was isolated and identified. The extraction of caffeine was confirmed by HighPerformance Liquid Chromatography (HPLC ) and its purity was identified comparing to the standard caffeine. The results showed the effect of three different concentrations (2.5, 5, 10 mg/ kg )of caffeine on the histomorphological changes in the cecum tissue of the E. histolytica-infected mice. After treatment with these concentrations, the infected cecumtissue was either recovered to the normal histomorphological conditionor got an increase in the underlying cells number, an increase in the mucin secretion and few leaching of inflammatory cells.
Keyword: Entamoebahistolytica, Green tea, Cecum
DOI: https://doi.org/10.31838/ijpr/2020.12.01.042
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