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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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AN OVERVIEW ON RECENT ADVANCES IN POLYMERIC NANOPARTICLES AS A COLLOIDAL DRUG CARRIER

Author: ABHIJIT CHOUDHURY, LALDINCHHANA
Abstract: Polymeric nanoparticles (PNPs) are very popular due to availability of a wide variety of polymers with molecular weights and physical properties capable of being modified. They are utilized as carriers for drugs which are toxic, water-insoluble, or unstable for better therapeutic effect with minimal adverse reactions. The PNPs are classified in two ways- one based on preparation method and the other based on type of polymer. PNPs are prepared by two methods- two step process and one step process. Two step process involves emulsification followed by preparation of nanoparticles whereas in one step process the nanoparticles are obtained directly. Both the processes are further subdivided into three types each. The characterization of nanoparticles is based on size distribution, surface properties, stability and polymer drug interactions. The polymeric nanoparticles have a wide variety of applications in the field of diagnostic and therapeutics and provide various advantages over conventional therapy which includes high specificity, prolonged circulatory half-life, reduced systemic toxicity, controlled and modified drug release and active drug targeting. The present article emphasizes on the types, methods of preparation, characterization and recent advances in the application of PNPs as a colloidal drug carrier.
Keyword: Polymer, Emulsification, Photoresponsive drug delivery, Biocompatibilitty, Polymeric nanoparticle
DOI: https://doi.org/10.31838/ijpr/2020.12.01.010
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