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AN OVERVIEW ON RECENT ADVANCES IN POLYMERIC NANOPARTICLES AS A COLLOIDAL DRUG CARRIER
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| Author:
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ABHIJIT CHOUDHURY, LALDINCHHANA
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| Abstract:
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Polymeric nanoparticles
(PNPs) are very popular due to availability of a wide variety of polymers with molecular weights and physical properties
capable of being modified. They are utilized as carriers for drugs which are toxic, water-insoluble, or unstable for better therapeutic effect with
minimal adverse reactions. The PNPs are classified in two ways- one based on preparation method and the other based on type of polymer. PNPs
are prepared by two methods- two step process and one step process. Two step process involves emulsification followed by preparation of
nanoparticles whereas in one step process the nanoparticles are obtained directly. Both the processes are further subdivided into three types each.
The characterization of nanoparticles is based on size distribution, surface properties, stability and polymer drug interactions. The polymeric
nanoparticles have a wide variety of applications in the field of diagnostic and therapeutics and provide various advantages over conventional therapy
which includes high specificity, prolonged circulatory half-life, reduced systemic toxicity, controlled and modified drug release and active drug
targeting. The present article emphasizes on the types, methods of preparation, characterization and recent advances in the application of PNPs as a
colloidal drug carrier.
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| Keyword:
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Polymer, Emulsification, Photoresponsive drug delivery, Biocompatibilitty, Polymeric nanoparticle
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.01.010
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| Download:
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