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Structural, Spectral and Thermal Studies of Novel Tridentate Schiff Base Ligand Type (NOO) as Donor Atoms from Nalidixic Acid and 2-Aminophenol and Metal Complexes and Evaluation of their Biological Activity
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| Author:
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HAWRAA SALLOOM, SAJID M. LATEEF
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| Abstract:
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In this study, a novel Schiff base (E)-1-ethyl-4-(2-hydroxyphenylimino)-7-methyl-1,4-dihydro-1,8 naphthyridine3-carboxylic
acid (H2L) was synthesized from nalidixic acid and 2-Aminophenol and it's complexes
with metal ions M=VO, Mn, Co, Ni, Cu ,Zn, Pd and Pt in ethanol and acetic acid with mole ratio
(M:L) (1:2). All complexes have general composition ([VO (L) (H2O)], K2 [Mn(L)2]H2O, K2 [Co(L)2]
H2O, K2 [Ni(L)2], [Zn(L) (H2O)], [Pd(KL)2] H2O, [Pt(KL)Cl2]) where: L
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= C18H16N3O3. The ligand and all
complexes were characterized by modern spectroscopic (FT-IR, UV Vis,
HNMR, Mass spectroscopy, atomic
absorption), along with elemental microanalysis, magnetic susceptibility measurements, thermal analyses,
chloride content and molar conductance. In addition to evaluated their biological activity against one type of
bacterial and one type fungus. Based on date for all techniques we suggested that all the prepared complexes
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have octahedral geometry accept [Zn(L)(H2O)] tetrahedral geometry and [Pd(KL)2]H2O Square planer
geometry, [VO (L) (H2O)] square pyramidel. The value of antibacterial activity of this prepared complexes
showed higher inhibition activity compared to the free ligand and starting material.
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| Keyword:
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Nalidixic Acid, 2-Aminophenol, Metal complexes, Biological activity.
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| EOI:
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| DOI:
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