*Five Years Citation in Google scholar (2016 - 2020) is. 1451*   *    IJPR IS INDEXED IN ELSEVIER EMBASE & EBSCO *       

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
The chemical composition, antibacterial activity and mechanism of action essential oil of red ginger (Zingiber officinale var. Rubra) species from Bogor West Java Indonesia

Author: , DIKI PRAYUGO WIBOWO, RIA MARIANI, SITI USWATUN HASANAH, DIAH LIA AULIFA
Abstract: Ethnopharmacological relevance: Zingiber is a large and highly diverse genus of plants with medicinal and aromatic use. It spread in different environments in the tropics. Aim of the study: To evaluate the antibacterial potential of essential oils from red ginger (Zingiber officinale var. Rubra) rhizome from the Bogor area in West java Indonesia against Staphylococcus aureus and to examine its possible related mechanisms. The study was undertaken to scientifically validate the traditional use of red ginger. Materials and methods: The essential oil was extracted from the Rhizome of red ginger by hydrodistillation.The chemical composition of essential oils has been investigated using gas chromatographymass spectrometry (GC-MS). Antibacterial activity was evaluated by the method for microdilution of six bacteria by determining the value of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The antibacterial mechanism was assessed by scanning electron microscope (SEM). Results: 40 components were identified from the essential oil. Citral (18.83%), Z Citral (14.21%), Camphene (8.77%), 1,8-Cineole (5.17%) and Alfa cendrene (4.42%) they are the main component in essential oil. The essential oil showed good antibacterial activity against S. aureus, with the lowest MIC of 125 µg.mL -1 and MBC values of above 1000 µg.mL -1 . Essential oils can cause damage to bacterial cells through the destruction of cellular proteins. scanning by scanning electron microscopy (SEM) shows that essential oils change the morphology of the cell wall and membrane. Conclusions: The essential oil of red ginger has potential antibacterial activities against S. aureus. The antibacterial mechanism of essential oils based on SEM observations is thought to cause permanent damage to cell walls and membranes. Further research into the chemical content and pharmacological effects are needed to scientifically validate the use of the community.
Keyword: Zingiber; Essential oil; Antibacterial activity; Antibacterial mechanism; Staphylococcus aureus
Download: Request For Article
 




ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events
SCImago Journal & Country Rank

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free