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The chemical composition, antibacterial activity and mechanism of action essential oil of red ginger (Zingiber officinale var. Rubra) species from Bogor West Java Indonesia
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| Author:
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, DIKI PRAYUGO WIBOWO, RIA MARIANI, SITI USWATUN HASANAH, DIAH LIA AULIFA
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| Abstract:
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Ethnopharmacological relevance: Zingiber is a large and highly diverse genus of plants with medicinal and
aromatic use. It spread in different environments in the tropics. Aim of the study: To evaluate the
antibacterial potential of essential oils from red ginger (Zingiber officinale var. Rubra) rhizome from the Bogor
area in West java Indonesia against Staphylococcus aureus and to examine its possible related mechanisms. The
study was undertaken to scientifically validate the traditional use of red ginger. Materials and methods: The
essential oil was
extracted
from
the Rhizome of
red
ginger
by
hydrodistillation.The chemical composition of essential oils has been investigated using gas chromatographymass
spectrometry
(GC-MS).
Antibacterial activity was evaluated by the method for microdilution of six
bacteria by determining the value of minimum inhibitory concentration (MIC) and minimum bactericidal
concentration (MBC). The antibacterial mechanism was assessed by scanning electron microscope (SEM).
Results: 40 components were identified from the essential oil. Citral (18.83%), Z Citral (14.21%), Camphene
(8.77%), 1,8-Cineole (5.17%) and Alfa cendrene (4.42%) they are the main component in essential oil. The
essential oil showed good antibacterial activity against S. aureus, with the lowest MIC of 125 µg.mL
-1
and MBC
values of above 1000 µg.mL
-1
. Essential oils can cause damage to bacterial cells through the destruction of
cellular proteins. scanning by scanning electron microscopy (SEM) shows that essential oils change the
morphology of the cell wall and membrane. Conclusions: The essential oil of red ginger has potential
antibacterial activities against S. aureus. The antibacterial mechanism of essential oils based on SEM
observations is thought to cause permanent damage to cell walls and membranes. Further research into the
chemical content and pharmacological effects are needed to scientifically validate the use of the community.
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| Keyword:
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Zingiber; Essential oil; Antibacterial activity; Antibacterial mechanism; Staphylococcus aureus
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| EOI:
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| DOI:
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