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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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An advancement of collagen and curcumin nanoparticles with surfactan using sld method for wound healing application: experimental study on rabbits

Author: SEPTIANA INDRATMOKO, ANDI TENRI NURWAHIDAH , MAULIDINA INTEN AMRI, ELISA ISSUSILANINGTYAS
Abstract: Wounds are the loss or damage of some body tissues. Collagen is a key component in the process of wound healing in the formation of tissues and organs. In addition to collagen, curcumin can also accelerate wound healing. To improve its potential application, the formulation is carried out by making nanoparticles. Determination of the optimum formula is using the Simplex Lattice Design method. This study aimed to determine the effect of collagen and curcumin nanoparticle spray with tween 80 and PEG 400 as rabbits wound healers (Orytolagus cuniculus). This research was carried out experimentally. The test animals used were 5 male rabbits (Oryctolagus cuniculus), divided randomly into 5 groups. Consists of negative control, positive controls (povidone iodine), and collagen nanoparticles spray dose 1, dose 2, and dose 3 groups. Observations were made by measuring the length of the wound and the time of wound closure. Data were analyzed by One Way Anova and Post Hoct LSD to determine differences between treatment groups. The optimum result of tween 80, PEG 400 and shark results in a ratio of 6: 1: 1. The results of particle size were 17.4 nm, zeta potential profile was -2.0 mV, maximal drug loading 125 mg / 5mL and nanoparticle stability for 2 weeks. The results of the best wound healing activity test in rabbits were dose 3 with the concentration of collagen nanoparticle spray (0,145 mg) and curcumin (0,08 mg) with wound closure time on 7th day. Collagen and curcumin spray nanoparticles have a wound healing effect that was faster than positive control and negative control, but did not produce significant differences between groups.
Keyword: Curcumin, Collagen, Wounds, Nanoparticles, Simplex Lattice Design.
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