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Oxidative Stress And Endothelium Disfunction In Athletes As A Risk Factor For Developing Cardiomyopathy Of Overstrain
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| Author:
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V.S. VASILENKO, Z.V. LOPATIN, V.V. OREL , A.K.KHUSHTOVA
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| Abstract:
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Investigation of the effect of oxidative stress and the endohelium dysfunction in athletes is a focal trend in the study of
factors contributing to the development of cardiomyopathy of overstrain. Long tolerance exercises can negatively
affect the anti-oxidant status of athletes. Oxidative stress accompanying sport exercises can be an additional
pathogenetic mechanism of tthe endothelium dysfunction. There is an increasing number of papers reporting
endothelium dysfunction development iunder the influence of high exercise load in athletes.Relying on the analysis of
the special scientific literature this paper reveals the mechanisms of developing the endothelium dysfunction and
cardiomyopathy of overstrain resulting from an oxidative stress in athletes. Modern findings of authors from both
this country and abroad have been analysed. Basing on the study of the scientific sources describing possible metabolic
changes eventually resulting from the oxidizing stress, special attention has been paid to the influence of the oxidative
stress on the endothelium function. In its turn, the endothelium dysfunction is a factor decreasing adaptability of the
athletes’ cardio-vascular system to physical load ,which leads to cardiomyopathy of overstrain development.
Correction of the endothelium dysfunction has become a pressing problem of the present. Data of studies of the
endotheliocytes functional state criteria, as well as of any ways of medication affecting them can be successfully
applied in diagnosing and treating cardiomyopathy of overstrain in athletes.
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| Keyword:
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oxidative(oxidizing) stress, endothelium, athletes, heart.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.01.026
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| Download:
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