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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Orodispersible tablet Based on amorphous surface solid dispersions of Roxithromycin

Author: NARENDRA YADAV, PRABHAT KUMAR UPADHYAY, MANISH KUMAR, BEENA KUMARI
Abstract: The aim of this study was to carry out the formation and characterization of amorphous solid dispersions (SDs) as orodispersible tablets (ODT) were investigated using roxithromycin as a poorly water-soluble drug. Surface solid dispersion was prepared by using the solvent evaporation method and the tablets are prepared by direct compression method. In the present study, different evaluation parameters were performed such as Drug Excipient Compatibility Study, Thin Layer Chromatographic Study. Evaluation of surface solid dispersion was done by calculating drug content, In-Vitro Dissolution of Surface Solid Dispersion (SSD), SEM, DSC. The prepared orodispersible tablets were also evaluated for all derived properties and in vitro release studies. And finally, comparison studies were carried out. Formulation F3 shows maximum dissolution among surface solid dispersion formulations. It has been seen by increasing the concentration the dissolution was increased. Mechanism of improvement of dissolution characteristics of Roxithromycin by SSD3 was adsorption on the surface of the carrier. Tablet formulation F3 made with Surface Solid Dispersion with a disintegration time of 11 seconds, high water absorption of 78% by weight, by wetting time 6 seconds and cumulative drug release of 98% proved to be higher than the tablet made with solid dispersion. Comparison of surface solid dispersion and an orodispersible tablet was done. Both the techniques are best proven in the solubility enhancement. Selected formulations from both the dosage form show 94 and 97 % drug release respectively.
Keyword: Roxithromycin, in-vitro drug release, orodispersible tablet, solvent evaporation, Thin Layer Chromatographic, solid dispersion.
DOI: https://doi.org/10.31838/ijpr/2019.11.04.089
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