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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Chemical Constituents, Antimicrobial and Antiinflammatory Evaluations of Various Extracts ofSuaeda vera Forssk. Growing in Saudi Arabia

Author: ARAFA MUSA
Abstract: Investigation of the chemical constituents, in-vitro antimicrobial and anti-inflammatory activities of Suaeda veraresulted in isolation of four known metabolites for the first time. The isolateswere elucidated and characterized through different spectroscopic techniques (NMR, UV and Mass spectrometry), and throughcomparison with authentic standards.They were identified as ß-sitosterol-3-O-ß-D-glucoside (1), acacetin (2), quercetin (3) andquercetin 3-O-ß-D-glucoside (4). Ethanolic extract was tested for its anti-inflammatory effect by Carrageenan-induced rat paw edema, while both ethyl acetate and ethanolic extracts were evaluated for their antimicrobial activity bythedisc-agardiffusion method.Oral injection ofethanolic extract in doses of 200, 400 and 600 mg/kg exerted promising anti-inflammatory effect compared to diclofenac sodium (voltaren®) as a standard control.Both ethanol and ethyl acetate extracts showed significant antimicrobial effect against gram negative E. coli (inhibition zone: 20-25 mm) and moderate effect on Staphylococcusaureus and Candida albicans (inhibition zone: 8-13 mm). EtOAc fraction exhibited more significance than EtOH fraction as an antimicrobial agent.
Keyword: Suaedavera; flavonoids; antimicrobial; anti-inflammatory.
DOI: https://doi.org/10.31838/ijpr/2019.11.04.098
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