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Chemical Constituents, Antimicrobial and Antiinflammatory Evaluations of Various Extracts ofSuaeda vera Forssk. Growing in Saudi Arabia
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| Author:
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ARAFA MUSA
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| Abstract:
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Investigation of the chemical constituents, in-vitro antimicrobial and anti-inflammatory activities of Suaeda
veraresulted in isolation of four known metabolites for the first time. The isolateswere elucidated and
characterized through different spectroscopic techniques (NMR, UV and Mass spectrometry), and
throughcomparison with authentic standards.They were identified as ß-sitosterol-3-O-ß-D-glucoside (1), acacetin
(2), quercetin (3) andquercetin 3-O-ß-D-glucoside (4). Ethanolic extract was tested for its anti-inflammatory effect
by Carrageenan-induced rat paw edema, while both ethyl acetate and ethanolic extracts were evaluated for their
antimicrobial activity bythedisc-agardiffusion method.Oral injection ofethanolic extract in doses of 200, 400 and
600 mg/kg exerted promising anti-inflammatory effect compared to diclofenac sodium (voltaren®) as a standard
control.Both ethanol and ethyl acetate extracts showed significant antimicrobial effect against gram negative E. coli
(inhibition zone: 20-25 mm) and moderate effect on Staphylococcusaureus and Candida albicans (inhibition zone: 8-13
mm). EtOAc fraction exhibited more significance than EtOH fraction as an antimicrobial agent.
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| Keyword:
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Suaedavera; flavonoids; antimicrobial; anti-inflammatory.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.04.098
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| Download:
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Request For Article
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