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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Contribution of the antiradical mechanism to the total antioxidant activity of heterocyclic compounds

Author: S.S. ZYKOVA, S.V. PONOSOV
Abstract: The contribution of the antiradical mechanism to the total antioxidant activity of various heterocyclic compounds is studied. It was found that the predominance of the antiradical mechanism in antioxidant activity is largely determined by the presence of a group and a methoxy group in the composition of a phenyl radical substituent. Analysis of the correlation of growth of Escherichia coli M 17 in the medium with H these substances showed that benzoxazines did not show the antioxidant activity. High prooxidant activity was found in benzoxazines having methyl or tert binding activity, but unlike phenacylpyrroles, benzoxazines practically showed only prooxidant activity, since the protective effect of the compounds was not observed under the action of H culture. In addition, the study showed that the combina chemical compounds allows to specify their antioxidant/prooxidant effects.
Keyword: antiradical activity, antioxidant activity, correlation, benzoxazines.
DOI: https://doi.org/10.31838/ijpr/2019.11.04.097
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