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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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Effects of repeatedly subcutaneous injection of silver nanoparticles on liver and kidney functions in male rats

Author: SHAYMAA MADHKHOOR, MAKEYA ABDULJABBAR HASOUN
Abstract: Background and aims: Nanoparticles (NPs) are increasingly being used in a wide-range of sciences especially in human medicine; however, little is known about the detrimental concurrent effects generated by the use of those NPs. According to that, the present investigation was carried out to discover the effects of repeatedly subcutaneous injection of silver nanoparticles (SNPs) on liver and kidney functions in male albino Wister rats. Materials and methods: The experiment included the use of 18 rats randomly divided into three groups (6 animals/group) according to the treatment they received as following: Distilled water, (DW) group, SNPs at 100PPM, (100PPM) group, and SNPs at 250PPM, (250PPM) group. The treatments were given using subcutaneous (S/C) injection/day for 21 days. The rats were acclimated to the housing, personals, equipment, etc. before receiving the treatments.In the day 22 of the experiment, all rats were anesthetized using chloroform to collect blood samples via cardiac puncture. Then, sera from those blood samples were separated and kept frozen until were analyzed using a full automated biochemistry machine for unveiling the hepatic and renal functions, which included, for the liver, total serum bilirubin (TSB), alkaline phosphatase (ALP), glutamic pyruvic transaminase (GPT), and glutamic oxaloacetic transaminase (GOT), and for the kidney, urea, creatinine (Cr), albumin (Alb), and total protein (TP). Results: The findings revealed that TSB, ALP, and GOT significantly (p?0.05) increased in both 100PPM and 250PPM groups when compared with that from the DW group. However, GPT showed significant (p?0.05) increases in 250PPM group only when compared with that from the DW group. For the renal functions, urea demonstrated significant (p?0.05) increases in both 100PPM and 250PPM groups when compared with that from the DW group.Moreover, Cr showed significant (p?0.05) increases in 250PPM group only when compared with that from the DW group. Furthermore, Alb recorded significant (p?0.05) decreases in both 100PPM and 250PPM groups when compared with that from the DW group. In addition, TP documented significant (p?0.05) increases in 250PPM group only when compared with that from the DW group. Conclusion: The current investigational experiment indicates that silver nanoparticles may induce damages to the liver and kidney leading to insufficiency in their functions.
Keyword: Kidney functions, liver functions, nanotechnology, silver nanoparticles.
DOI: https://doi.org/10.31838/ijpr/2019.11.04.046
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