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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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A brief review on Hydrophilic Interaction Liquid Chromatography (HILIC)

Author: SHEETAL RATHOD, DR. SHAILESH V. LUHAR, DR. SACHIN B. NARKHEDE
Abstract: This review shows an overview about the Hydrophilic interaction liquid chromatography which provide an another point of view for separation of small polar compound. The HILIC is a technique which uses an organic/ aqueous modifier mobile phase with high organic solvent concentration and stationary phase with hydrophilic nature. The characteristic of the stationary phase is discussed which may affect and in some cases mobile phase composition choice is limited also limit the ion strength, retention strength .The mechanism of HILIC is based on partition chromatography by modification is needed. The application of HILIC is discuss along with its limitations.
Keyword: HILIC, separation, stationary phase
DOI: https://doi.org/10.31838/ijpr/2019.11.04.020
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