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Evaluation of the Effect of Caffeine on Apnea of Preterm Neonates Hospitalized in Intensive care unit: A clinical trial
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| Author:
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ALIREZA MOTLAGH, PARASTO TOSI, MITRA RAHIMZADEH
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| Abstract:
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Introduction: Respiratory disorders are one of the most important problems seen in preterm neonates and
the treatment or prevention of these disorders is crucial to improve the condition of the neonates. The
objective of this study was to evaluate the effect of caffeine on the prevention of apnea in neonates
hospitalized in Bahonar and Kamali hospitals in Karaj.
Methodology: In this double-blinded randomized clinical trial, 48 neonates hospitalized in Bahonar and Kamali
hospitals of Karaj in 2017-2018 were randomly assigned to one of two groups of intervention and control
using the randomized numbers table. The intervention group received 20 mg/kg intravenous caffeine as the
initial dose on the first day and 5 mg / kg intravenous caffeine daily as the maintenance dose for the first 7 days
of life and the control group received normal saline at equal volume (approximately 3 cc) for the first 7 days of
life. Then, treatment outcomes including bradycardia, cyanosis and apnea were compared in two groups.
Results: The results revealed no statistically significant difference between the two groups in terms of
treatment indicators, including bradycardia, cyanosis and apnea (P> 0.05) and no significant difference was
found between the two groups in terms of reduction in oxygen saturation. Moreover, the level of tachycardia
and dependency on oxygen was not significantly different in two groups.
Conclusion: Apnea is a common problem in preterm and low birth weight neonates. The results of this study
revealed that caffeine had no significant impact on the prevention of apnea in preterm neonates, but it had an
effect on reducing oxygen saturation. Thus, further studies with larger sample size are recommended in this
regard and more studies are recommended to compare the preventive and therapeutic effects of caffeine on
apnea and other complications of preterm neonates.
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| Keyword:
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Caffeine, Apnea, Preterm neonate
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.04.117
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| Download:
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