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Immunity of the Nasal Mucosa in Premature Infants of the First Year of Life
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| Author:
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ALBINA KALIMULLINA, VICTORIA AMIROVA, LILIYA AZNABAEVA, SVETLANA LARIONOVA, NATALIA SHAFAZHINSKAYA, NIKITA LOGACHEV, NIKOLAI MAKSIMYUK
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| Abstract:
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The indices of immunity on the nasal mucosa were studied in 47 children of the first year of life born
prematurely at the gestational age of 28-37 weeks. ELISA test was used to determine antibodies (IgA, IgG, IgE)
and cytokines (TNF-a, IL-1ß, IF-?) of nasal mucosa washes. The study found that premature infants had
transient deficiency of IgG at the age of 6 months (2.08 (0.78-6.99) mg/ml) and low IgE indices at the age of 12
months (0.89 (0.47-of 1.32) ng/ml) against hyperproduction of IL-1ß and low idices of IF-? at the age of 6
months (7.51 (4.84-13.82) pg/ml) and 12 months (8.28 (4.70-12.07) pg/ml). Infants born at the gestational age
of 28-32 weeks had the worst antibody and antiviral protection. The findings may be useful in the development
of measures for the prevention and treatment of inflammatory respiratory infections in premature infants.
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| Keyword:
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immunity of the nasal mucosa, nasal cavity, premature infants
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.04.115
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| Download:
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