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Enhancement of Dissolution Rate of Lansoprazole Using Liquisolid Tablet Technique
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| Author:
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UPLOADED BY-ADMIN, KASTURE S.V., GONDKAR S.B., DAREKAR A.B., DASH PRIYOBRATA, BHAMBAR K.V.
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| Abstract:
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Lansoprazole is a water-insoluble, highly permeable drug that shows a high inter-subject variation of bioavailability and
the rate of its oral absorption is often controlled by the dissolution rate in the intestine. The purpose of present study was to
improve lansoprazole dissolution through its formulation into liquisolid tablets and then to investigate in vitro performance
of prepared liquisolid systems. By use of this technique, liquid medications such as solutions or suspensions of water insoluble
drugs in suitable nonvolatile liquid vehicles can be easily converted into powders with acceptable flow properties and
compression behavior by using suitable powder excipients. Fourier Transform Infrared and Differential Scanning Calorimetry
were used for evaluation of physicochemical properties of Lansoprazole in liquisolid tablets. Scanning Electron Microscopy
was used to assess morphological characteristics of liquisolid formulation. Enhanced drug release profiles due to increased
wetting properties and surface of drug available for dissolution was obtained in case of liquisolid tablets.
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| Keyword:
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Lansoprazole, Water-insoluble, Liquisolid tablets
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| EOI:
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| DOI:
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