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Formulation and Evaluation of Transdermal Delivery of Enalapril maleate
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UPLOADED BY-ADMIN, M. SABAREESH, SELVARAJ. S, KARTHIKEYAN. J, SONPAL. R. N
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| Abstract:
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The present work was designed to develop the Transdermal matrix patches of Enalapril maleate, an angiotensin converting
enzyme inhibitor. The Matrix patches were prepared by solvent casting technique with propylene glycol (3%) as
plasticizer and Water as solvent. The patches were formulated by using hydroxyl propyl methyl cellulose alone having drug
and polymer ratio 1:5, 1:7, 1:9 and one more patch was formulated using hydroxyl propyl methyl cellulose with permeation
enhancer, Span 80 (1%) in ratio of 1:9. The compatibility of the drug and the polymer was studied by Fourier Transform
Infrared spectroscopy. The results suggested there is no interaction between the drug and the polymer uses. Enalapril maleate
patch were characterized by physicochemical characteristics like thickness, weight variation, drug content, folding endurance,
percentage moisture loss, percentage moisture absorption, water vapour transmission rate, tensile strength and ex vivo
skin permeation studies were performed using Franz’s diffusion cell. The formulations exhibited uniform thickness, folding
endurance, uniformity of weight and drug content. Kinetic data revealed that the drug release followed zero order nonfickian
diffusion mechanism. The results of the study show that Enalapril maleate could be administered transdermally
through the matrix type TDDS for effective control of hypertension; congestive heart failure and angina pectoris.
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Enalapril maleate, Transdermal patch, Solvent casting technique, Hydroxy propyl methyl cellulose, ex vivo skin permeation studies.
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