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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Formulation and Evaluation of Transdermal Delivery of Enalapril maleate

Author: UPLOADED BY-ADMIN, M. SABAREESH, SELVARAJ. S, KARTHIKEYAN. J, SONPAL. R. N
Abstract: The present work was designed to develop the Transdermal matrix patches of Enalapril maleate, an angiotensin converting enzyme inhibitor. The Matrix patches were prepared by solvent casting technique with propylene glycol (3%) as plasticizer and Water as solvent. The patches were formulated by using hydroxyl propyl methyl cellulose alone having drug and polymer ratio 1:5, 1:7, 1:9 and one more patch was formulated using hydroxyl propyl methyl cellulose with permeation enhancer, Span 80 (1%) in ratio of 1:9. The compatibility of the drug and the polymer was studied by Fourier Transform Infrared spectroscopy. The results suggested there is no interaction between the drug and the polymer uses. Enalapril maleate patch were characterized by physicochemical characteristics like thickness, weight variation, drug content, folding endurance, percentage moisture loss, percentage moisture absorption, water vapour transmission rate, tensile strength and ex vivo skin permeation studies were performed using Franz’s diffusion cell. The formulations exhibited uniform thickness, folding endurance, uniformity of weight and drug content. Kinetic data revealed that the drug release followed zero order nonfickian diffusion mechanism. The results of the study show that Enalapril maleate could be administered transdermally through the matrix type TDDS for effective control of hypertension; congestive heart failure and angina pectoris.
Keyword: Enalapril maleate, Transdermal patch, Solvent casting technique, Hydroxy propyl methyl cellulose, ex vivo skin permeation studies.
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