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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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ROLE OF AMIODARONE IN ACUTE MYOCARDIAL INFARACTION INDUCED VENTRICULAR TACHYCARDIA IN PATIENTS WITH LEFT ANTERIOR DESCENDING ARTERY INVOLVEMENT

Author: SREEKRISHNAN PARASURAMAN, DELCEY REACHEL VARGHESE, GIREESH KUMAR
Abstract: One of the most frequent causes of death is acute myocardial infarction induced ventricular arrhythmia. However, improvement in arrhythmia detection and treatment had a major impact on outcomes from ventricular arrhythmia associated acute MI, resulting in improved hospital prognosis .In our study, Left Anterior Descending Artery was the culprit vessel in majority of cases of Acute Coronary Syndrome. Here we highlight the role of amiodarone in acute myocardial infarction induced ventricular tachycardia in patients with left anterior descending artery involvement is the primary objective. Amiodarone appears to be effective in reducing arrhythmias and sudden cardiac death when used prophylactically in the post myocardial infarction (MI) period. Incidence of VT and VF / CA in patients who presented with Acute Coronary Syndrome and Normal LV Function were 12.5% and 14% respectively. Mortality was higher in VF / CA (20/28) group compared to VT group (11/25). The benefit of early administration of amiodarone, especially when given intravenously, may be related to its beta blocking effect. In our study we suggest that in those patients having suspected lesion in the left anterior descending artery that have delay in achieving reperfusion can be initiated with antiarrythmic agents like amiodarone. Further research is needed to understand the prophylactic management of amiodarone in patients having suspected lesion in the left anterior descending artery.
Keyword: ventricular arrhythmia, myocardial infarction, left anterior descending artery
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