Impact Factor for Five Years is 1.55 (2012 - 2016). 22nd National Convention of Society of Pharmacognosy & International Conference. For more details visit https://ncsp.ganpatuniversity.ac.in/index.php

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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

ISSN
0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

Current Issue
Article In Press
Antioxidant activity and total phenolic content in 15 commonly used cucurbits in Tarai region of Kumaun, Uttarakhand.
Analytical Method Development and Validation for the Simultaneous Estimation of Ambroxol Hydrochloride and Guaiphenesin in Syrup Dosage form by RP-HPLC
Role of NMDA receptor antagonist in ethanol withdrawal syndrome
STABILITY INDICATING LC-MS/MS METHOD FOR QUANTIFICATION OF IBRUTINIB IN HUMAN PLASMA
A review on drug: Amantadine
Chemopreventive and antioxidative activity of Carissa carandas extract against chemical induced skin tumorigenesis in mice
ROLE OF AMIODARONE IN ACUTE MYOCARDIAL INFARACTION INDUCED VENTRICULAR TACHYCARDIA IN PATIENTS WITH LEFT ANTERIOR DESCENDING ARTERY INVOLVEMENT
Extraction optimisation, fractionation, standardisation, in vitro antioxidant and anticholinesterase activity of fractions of Indian Propolis
Development of validated stability-indicating analytical method for simultaneous estimation of Atenolol and Hydrochlorothiazide in pharmaceutical combined dosage form by High Performance Thin Layer Chromatography.
Lung Cancer in Lifelong Never Smokers-Short Review
12
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IJPRT ISSUE

January - March 6 [1] 2014

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Article Detail

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Design and Development of Indian Propolis Loaded Poly (e -Caprolactone) Nanoparticles For Improved Anticancer Efficacy

Author: DR. SATHIYANARAYANAN LOHIDASAN, HARSHAD KAPARE , ARULMOZHI S , KAKASAHEB MAHADIK
Abstract: Propolis, a natural product obtained from apiculture and is well proven for its anticancer potential. Anticancer efficacy of propolis is limited to its poor water solubility and bioavailability. The present study was designed and investigated for development of ethanolic extract of Indian propolis (EEIP) loaded Poly (e-caprolactone) nanoparticles (EPL) to achieve improved solubility, sustained drug release and enhanced cytotoxic efficacy of EEIP. Formulation development, characterization and optimization were carried out by design of experiment approach. Developed formulations were evaluated in detail for nanoparticle characterization and in vitro cytotoxicity study. Developed nanoparticles showed particle size, and encapsulation efficiency of 190 ± 1 - 230 ± 2 nm and 62.66± 1.20 - 67.18± 1.80 % respectively. Optimized formulation EPL showed sustained drug release over a period of 48 h. Concentration of the drug needed for total growth inhibition of cells in a designed time period (TGI) was decreased by 33.06% for EPL as compared to EEIP in human breast cancer MCF-7 cells and 22.31% in human colon cancer cells HT-29 indicating improved cytotoxicity of EEIP. The study proven that the optimized EPL exhibited increased solubility, sustained drug release and enhanced in vitro cytotoxicity on MCF-7 and HT-29 cell lines in comparison with EEIP. Thus developed system may be served as potential nanocarrier in anticancer treatment.
Keyword: Indian propolis; Poly (e-caprolactone); Design of experiment; Sulforhodamine B (SRB) assay
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News & Events
22nd National Convention of Society of Pharmacognosy & International Conference. For more details visit https://ncsp.ganpatuniversity.ac.in
Impact Factor for five years is 1.55 (2012 - 2016)
Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477
Impact Factor for five years is 1.3 (2010 - 2014)