IJPR  artciles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 1.55 (2012 - 2016). 

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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

ISSN
0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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IJPRT ISSUE

January - March 6 [1] 2014

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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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PIPPHARMACON & IJPR 2018

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Article Detail

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STABILITY INDICATING LC-MS/MS METHOD FOR QUANTIFICATION OF IBRUTINIB IN HUMAN PLASMA

Author: SRIKANTH I.SRIKANTH, , A.PAMEELA RANI
Abstract: A simple, sensitive and speci?c liquid chromatography–electrospray ionization-mass spectrometry method was developed for the quantitative determination of Ibrutinib in human plasma. Sample preparation involved simple liquid–liquid extraction. Ibrutinib-D5 was used as internal standard. The separation of the analyte, internal standard and possible endogenous compounds were accomplished on a Shim-pack ODS column (150 mm×4.6 mm i.d., 5 µm) with methanol–water (98:2, v/v) as mobile phase. A Turbo-Ion spray source was interfaced between the HPLC and triple quadrupole mass spectrometer (MDS Sciex API 4000). The precursor-product ion m/z was 441.2 ? 84.1 m/z and 446.5 ? 84.1 m/z were used for quantification of an analyte and its IS. The method was validated over the range of 0.5–60 ng/mL and the results were acceptable. The method could offer the advantages of shorter run time (5.0 min) and lower LLOQ (0.5 ng/mL) with a decreased plasma volume requirement (250µL).
Keyword: Ibrutinib, LC-MS/MS, Human Plasma.
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News & Events

CiteScore 2016 -  0.09

SJR 2016 - 0.111

SNIP 2016 - 0.055

Impact Factor for five years is 1.55 (2012 - 2016)
Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477
Impact Factor for five years is 1.3 (2010 - 2014)