Impact Factor for Five Years is 1.55 (2012 - 2016). 22nd National Convention of Society of Pharmacognosy & International Conference. For more details visit https://ncsp.ganpatuniversity.ac.in/index.php

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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

ISSN
0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

Current Issue
Article In Press
Antioxidant activity and total phenolic content in 15 commonly used cucurbits in Tarai region of Kumaun, Uttarakhand.
Analytical Method Development and Validation for the Simultaneous Estimation of Ambroxol Hydrochloride and Guaiphenesin in Syrup Dosage form by RP-HPLC
Role of NMDA receptor antagonist in ethanol withdrawal syndrome
STABILITY INDICATING LC-MS/MS METHOD FOR QUANTIFICATION OF IBRUTINIB IN HUMAN PLASMA
A review on drug: Amantadine
Chemopreventive and antioxidative activity of Carissa carandas extract against chemical induced skin tumorigenesis in mice
ROLE OF AMIODARONE IN ACUTE MYOCARDIAL INFARACTION INDUCED VENTRICULAR TACHYCARDIA IN PATIENTS WITH LEFT ANTERIOR DESCENDING ARTERY INVOLVEMENT
Extraction optimisation, fractionation, standardisation, in vitro antioxidant and anticholinesterase activity of fractions of Indian Propolis
Development of validated stability-indicating analytical method for simultaneous estimation of Atenolol and Hydrochlorothiazide in pharmaceutical combined dosage form by High Performance Thin Layer Chromatography.
Lung Cancer in Lifelong Never Smokers-Short Review
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January - March 6 [1] 2014

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STABILITY INDICATING LC-MS/MS METHOD FOR QUANTIFICATION OF IBRUTINIB IN HUMAN PLASMA

Author: SRIKANTH I.SRIKANTH, , A.PAMEELA RANI
Abstract: A simple, sensitive and speci?c liquid chromatography–electrospray ionization-mass spectrometry method was developed for the quantitative determination of Ibrutinib in human plasma. Sample preparation involved simple liquid–liquid extraction. Ibrutinib-D5 was used as internal standard. The separation of the analyte, internal standard and possible endogenous compounds were accomplished on a Shim-pack ODS column (150 mm×4.6 mm i.d., 5 µm) with methanol–water (98:2, v/v) as mobile phase. A Turbo-Ion spray source was interfaced between the HPLC and triple quadrupole mass spectrometer (MDS Sciex API 4000). The precursor-product ion m/z was 441.2 ? 84.1 m/z and 446.5 ? 84.1 m/z were used for quantification of an analyte and its IS. The method was validated over the range of 0.5–60 ng/mL and the results were acceptable. The method could offer the advantages of shorter run time (5.0 min) and lower LLOQ (0.5 ng/mL) with a decreased plasma volume requirement (250µL).
Keyword: Ibrutinib, LC-MS/MS, Human Plasma.
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Chemical Abstract Services
Scopus (Elsevier) (Re-Application is Under Process)
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Ulrich's International Periodical Dictionary
Indian Science Abstract
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News & Events
22nd National Convention of Society of Pharmacognosy & International Conference. For more details visit https://ncsp.ganpatuniversity.ac.in
Impact Factor for five years is 1.55 (2012 - 2016)
Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477
Impact Factor for five years is 1.3 (2010 - 2014)