Impact Factor for Five Years is 1.55 (2012 - 2016). 22nd National Convention of Society of Pharmacognosy & International Conference. For more details visit https://ncsp.ganpatuniversity.ac.in/index.php

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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

ISSN
0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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A review on drug: Amantadine
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Extraction optimisation, fractionation, standardisation, in vitro antioxidant and anticholinesterase activity of fractions of Indian Propolis
Development of validated stability-indicating analytical method for simultaneous estimation of Atenolol and Hydrochlorothiazide in pharmaceutical combined dosage form by High Performance Thin Layer Chromatography.
Lung Cancer in Lifelong Never Smokers-Short Review
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January - March 6 [1] 2014

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STABILITY INDICATING HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF HEPATITIS C VIRUS NS5B INHIBITOR DRUGS SOFOSBUVIR AND LEDIPASVIR IN THEIR DOSAGE FORMS

Author: SIVA , CHINTALA RAMBABU
Abstract: A simple, accurate, isocratic stability indicating RP–HPLC method for the determination of sofosbuvir and ledipasvir in pure and in pharmaceutical formulations. Method was developed using methanol and acetate buffer in 78:22 (v/v) ratio as mobile phase at pH 4.9 using Agilent ZORBAX Eclipse Plus C18 (250 mm x 4.6 mm, 5µm) column as stationary phase. The flow rate and detection wavelength were 1.0 mL/min and 228 nm respectively. The linearity range of the method was found to be 4.5-27 µg/mL for ledipasvir and 20-120 µg/mL for sofosbuvir. The developed method was validated as per ICH guidelines and the results of all the validation parameters were well within acceptable limits. The degradation products formed during different stress conditions in stability studies were separated from both drugs and also from individual degradation products. The results obtained in this research work clearly indicated that the developed method is simple, selective, precise, accurate, robust and rugged. Hence, this validated method can be applied for the simultaneous estimation of sofosbuvir and ledipasvir in commercially available formulation sample.
Keyword: sofosbuvir, ledipasvir, HPLC, method development, Validation, Forced degradation
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22nd National Convention of Society of Pharmacognosy & International Conference. For more details visit https://ncsp.ganpatuniversity.ac.in
Impact Factor for five years is 1.55 (2012 - 2016)
Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477
Impact Factor for five years is 1.3 (2010 - 2014)