Impact Factor for Five Years is 1.55 (2012 - 2016). 22nd National Convention of Society of Pharmacognosy & International Conference. For more details visit https://ncsp.ganpatuniversity.ac.in/index.php

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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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IJPRT ISSUE

January - March 6 [1] 2014

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Article Detail

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Q-ABSORBANCE RATIO METHOD FOR SIMULTANEOUS DETERMINATION OF ZONISAMIDE AND BUPROPION IN SYNTHETIC MIXTURE

Author: PATEL BHARATBHAI, PARESH U. PATEL, PATEL RINAL
Abstract: A simple and sensitive spectrophotometric method based on Q - absorbance ratio was developed for the simultaneous estimation of Zonisamide and Bupropion in pharmaceutical synthetic mixture. Q - absorbance ratio method based on formation of Q-absorbance equation at two wavelengths, one is isoabsorptive point and another is the ?-max of one of the two drugs. Absorbance are measured at two selected wavelengths, one is 241.5 nm (isoabsorptive point) and another being 246 nm (?-max of BUP). The two drugs comply with beer lambert’s law over the linearity range of 4-28 µg/ml. The method was validated as per ICH guideline rules in terms of linearity, accuracy (recovery study), precision (repeatability, intraday, interday validation), limit of detection, limit of quantification. All the validation parameters were found to be within acceptable limits. The method was found to be simple, sensitive, rapid, cost effective, accurate, and precise for the routine analysis of both the drugs in the binary mixture.
Keyword: Zonisamide, Bupropion, Q - absorbance ratio method, Binary mixture, Validation.
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22nd National Convention of Society of Pharmacognosy & International Conference. For more details visit https://ncsp.ganpatuniversity.ac.in
Impact Factor for five years is 1.55 (2012 - 2016)
Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477
Impact Factor for five years is 1.3 (2010 - 2014)