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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Q-ABSORBANCE RATIO METHOD FOR SIMULTANEOUS DETERMINATION OF ZONISAMIDE AND BUPROPION IN SYNTHETIC MIXTURE

Author: PATEL BHARATBHAI, PARESH U. PATEL, PATEL RINAL
Abstract: A simple and sensitive spectrophotometric method based on Q - absorbance ratio was developed for the simultaneous estimation of Zonisamide and Bupropion in pharmaceutical synthetic mixture. Q - absorbance ratio method based on formation of Q-absorbance equation at two wavelengths, one is isoabsorptive point and another is the ?-max of one of the two drugs. Absorbance are measured at two selected wavelengths, one is 241.5 nm (isoabsorptive point) and another being 246 nm (?-max of BUP). The two drugs comply with beer lambert’s law over the linearity range of 4-28 µg/ml. The method was validated as per ICH guideline rules in terms of linearity, accuracy (recovery study), precision (repeatability, intraday, interday validation), limit of detection, limit of quantification. All the validation parameters were found to be within acceptable limits. The method was found to be simple, sensitive, rapid, cost effective, accurate, and precise for the routine analysis of both the drugs in the binary mixture.
Keyword: Zonisamide, Bupropion, Q - absorbance ratio method, Binary mixture, Validation.
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0.12
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