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Antidepressive Effect of Nicotine - Role of Serotonergic System.
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UPLOADED BY-ADMIN, BHAVIN A. VYAS, RUCHI B. VYAS, SHRIKANT V. JOSHI, DHIRAJ S. KHANDELWAL, DESHBANDHU R. PACHAURI, SANJAY B. KASTURE
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| Abstract:
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Nicotine, a crucial component in tobacco, is a potent modulator of central nervous system and produces variety of actions.
Recent studies in animal model of depression suggest that nicotine has antidepressive effect. Since most of the treatments currently
employed as antidepressants improve serotonergic transmission, in present study we examine the suggested antidepressive
effect of nicotine and its possible interaction with the serotonergic system using forced swimming test. Nicotine (0.1, 0.2,
0.4 mg/kg, s.c.) exhibited reduced duration of immobility in forced swimming test. We found that decrease of immobility following
the treatment with nicotine was abolished by prior depletion of 5-HT with p-chlorophenylalanine. Fluoxetine, a selective
serotonin reuptake inhibitor failed to induce any effect per se but combination of fluoxetine and nicotine produce potentiation.
Buspirone (0.06 mg/kg, i.p.) potentiated nicotine’s antidepressive effect, while it was attenuated by buspirone (2.5 mg/kg,
i.p.). Thus, present study justify that serotonergic system may be involved in antidepressive effect of nicotine.
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Nicotine, Forced swimming test, serotonergic receptors, pCPA
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